Alistair I Roy
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Explore the profile of Alistair I Roy including associated specialties, affiliations and a list of published articles.
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10
Citations
224
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Recent Articles
1.
Brooks D, Wright S, Beattie A, McAllister N, Anderson N, Roy A, et al.
J Crit Care
. 2024 Mar;
82:154760.
PMID: 38492522
Purpose: Chest radiographs in critically ill patients can be difficult to interpret due to technical and clinical factors. We sought to determine the agreement of chest radiographs and CT scans,...
2.
Musgrave K, Scott J, Sendama W, Gardner A, Dewar F, Lake C, et al.
Thromb Res
. 2023 Jun;
228:10-20.
PMID: 37263122
Introduction: Tissue factor expression on monocytes is implicated in the pathophysiology of sepsis-induced coagulopathy. How tissue factor is expressed by monocyte subsets (classical, intermediate and non-classical) is unknown. Methods: Monocytic...
3.
Scott J, Ruchaud-Sparagano M, Musgrave K, Roy A, Wright S, Perry J, et al.
J Immunol
. 2021 Sep;
207(7):1776-1784.
PMID: 34497151
Acquired neutrophil dysfunction frequently develops during critical illness, independently increasing the risk for intensive care unit-acquired infection. PI3Kδ is implicated in driving neutrophil dysfunction and can potentially be targeted pharmacologically....
4.
Hellyer T, McAuley D, Walsh T, Anderson N, Morris A, Singh S, et al.
Ann Transl Med
. 2020 Aug;
8(13):840.
PMID: 32794522
No abstract available.
5.
Hellyer T, McAuley D, Walsh T, Anderson N, Morris A, Singh S, et al.
Lancet Respir Med
. 2019 Dec;
8(2):182-191.
PMID: 31810865
Background: Ventilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. Low concentrations of IL-1β and IL-8 in bronchoalveolar...
6.
Shankar-Hari M, Datta D, Wilson J, Assi V, Stephen J, Weir C, et al.
Intensive Care Med
. 2018 Oct;
44(11):1836-1848.
PMID: 30291379
Purpose: Reliable biomarkers for predicting subsequent sepsis among patients with suspected acute infection are lacking. In patients presenting to emergency departments (EDs) with suspected acute infection, we aimed to evaluate...
7.
Pinder E, Rostron A, Hellyer T, Ruchaud-Sparagano M, Scott J, Macfarlane J, et al.
Thorax
. 2018 Aug;
73(10):918-925.
PMID: 30064991
Background: Critically ill patients with impaired neutrophil phagocytosis have significantly increased risk of nosocomial infection. Granulocyte-macrophage colony-stimulating factor (GM-CSF) improves phagocytosis by neutrophils ex vivo. This study tested the hypothesis...
8.
Morris A, Datta D, Shankar-Hari M, Stephen J, Weir C, Rennie J, et al.
Intensive Care Med
. 2018 Jun;
44(5):627-635.
PMID: 29915941
Purpose: Cellular immune dysfunctions, which are common in intensive care patients, predict a number of significant complications. In order to effectively target treatments, clinically applicable measures need to be developed...
9.
Scott J, Harris G, Pinder E, Macfarlane J, Hellyer T, Rostron A, et al.
J Allergy Clin Immunol
. 2015 Sep;
137(2):535-44.
PMID: 26388312
Background: Neutrophils play a role in the pathogenesis of asthma, chronic obstructive pulmonary disease, and pulmonary infection. Impaired neutrophil phagocytosis predicts hospital-acquired infection. Despite this, remarkably few neutrophil-specific treatments exist....
10.
Hellyer T, Morris A, McAuley D, Walsh T, Anderson N, Singh S, et al.
Thorax
. 2014 Oct;
70(1):41-7.
PMID: 25298325
Background: Excessive use of empirical antibiotics is common in critically ill patients. Rapid biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator-acquired pneumonia (VAP). However, successful validation of the...