James F Whitfield
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Explore the profile of James F Whitfield including associated specialties, affiliations and a list of published articles.
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38
Citations
376
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Recent Articles
1.
Whitfield J, Rennie K, Chakravarthy B
Cells
. 2023 Jun;
12(12).
PMID: 37371088
The enormous, 2-3-million-year evolutionary expansion of hominin neocortices to the current enormity enabled humans to take over the planet. However, there appears to have been a glitch, and it occurred...
2.
Chiarini A, Armato U, Whitfield J, Dal Pra I
Curr Pharm Des
. 2017 Jul;
23(33):4990-5000.
PMID: 28699522
Understanding the pathophysiology of Alzheimer's disease (AD) in the principal human neural cells is necessary for finding therapeutics for this illness. To help do this, we have been using freshly...
3.
Whitfield J, Chiarini A, Dal Pra I, Armato U, Chakravarthy B
Cells
. 2015 Jul;
4(3):253-74.
PMID: 26184316
Dentate-gyral granule cells in the hippocampus plus dentate gyrus memory-recording/retrieving machine, unlike most other neurons in the brain, are continuously being generated in the adult brain with the important task...
4.
Chiarini A, Gardenal E, Whitfield J, Chakravarthy B, Armato U, Dal Pra I
Curr Pharm Biotechnol
. 2015 May;
16(8):696-706.
PMID: 25941885
The "amyloid cascade hypothesis" posits that an extracellular build-up of amyloid-β oligomers (Aβ-os) and polymers (fibrils) subsequently inducing toxic hyperphosphorylated (p)-Tau oligomers (p-Tau-os) and neurofibrillary tangles starts the sporadic late-onset...
5.
Dal Pra I, Armato U, Chioffi F, Pacchiana R, Whitfield J, Chakravarthy B, et al.
Neuromolecular Med
. 2014 Jun;
16(4):645-57.
PMID: 24948534
The excess vascular endothelial growth factor (VEGF) produced in the Alzheimer's disease (AD) brain can harm neurons, blood vessels, and other components of the neurovascular units (NVUs). But could astrocytes...
6.
Dal Pra I, Chiarini A, Gui L, Chakravarthy B, Pacchiana R, Gardenal E, et al.
Neuroscientist
. 2014 Apr;
21(1):9-29.
PMID: 24740577
Evidence has begun emerging for the "contagious" and destructive Aβ42 (amyloid-beta42) oligomers and phosphorylated Tau oligomers as drivers of sporadic Alzheimer's disease (AD), which advances along a pathway starting from...
7.
Armato U, Chiarini A, Chakravarthy B, Chioffi F, Pacchiana R, Colarusso E, et al.
Biochim Biophys Acta
. 2013 May;
1832(10):1634-52.
PMID: 23628734
The "amyloid-β (Aβ) hypothesis" posits that accumulating Aβ peptides (Aβs) produced by neurons cause Alzheimer's disease (AD). However, the Aβs contribution by the more numerous astrocytes remains undetermined. Previously we...
8.
Armato U, Chakravarthy B, Pacchiana R, Whitfield J
Int J Mol Med
. 2012 Nov;
31(1):3-10.
PMID: 23124509
The pathophysiological mechanisms underlying the onset and inexorable progression of the late‑onset form of Alzheimer's disease (AD) are still the object of controversy. This review takes stock of some most...
9.
Armato U, Bonafini C, Chakravarthy B, Pacchiana R, Chiarini A, Whitfield J, et al.
J Neurol Sci
. 2012 Jul;
322(1-2):137-40.
PMID: 22841885
Alzheimer's disease (AD) is the most common human neurodegenerative ailment, the most prevalent (>95%) late-onset type of which has a still uncertain etiology. The progressive decline of cognitive functions, dementia,...
10.
Dal Pra I, Chiarini A, Pacchiana R, Chakravarthy B, Whitfield J, Armato U
Mol Med Rep
. 2011 Apr;
1(2):173-8.
PMID: 21479393
Three steps lead to the development of full-blown sporadic or late-onset Alzheimer's disease or dementia (AD). In the young brain, amyloid β-(1-42) (Aβ 42) is a normal aggregation-prone protein product...