James F McGinnis
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Explore the profile of James F McGinnis including associated specialties, affiliations and a list of published articles.
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33
Citations
1069
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Recent Articles
1.
Wong L, Barkam S, Seal S, McGinnis J
Adv Exp Med Biol
. 2019 Dec;
1185:125-130.
PMID: 31884600
Intravitreal (IVT) injection of ophthalmic therapeutics is the most widely used drug delivery route to the posterior segment of the eye. We employed this method to deliver our inorganic, catalytic...
2.
Cai X, Seal S, McGinnis J
Mol Vis
. 2016 Oct;
22:1176-1187.
PMID: 27746672
Purpose: We have shown that cerium oxide nanoparticles (nanoceria), with unique characteristics and catalytic activities, are retained in the retina for more than 1 year after a single intravitreal injection...
3.
Cai X, McGinnis J
J Diabetes Res
. 2016 Feb;
2016:3789217.
PMID: 26881246
Diabetic retinopathy (DR) is one of the major complications of diabetes. Although great efforts have been made to uncover the mechanisms underlying the pathology of DR, the exact causes of...
4.
Cai X, McGinnis J
Adv Exp Med Biol
. 2015 Oct;
854:111-8.
PMID: 26427401
Age-related macular degeneration (AMD) is the leading cause of blinding diseases. The "dry" form of AMD is the most common form of AMD. In contrast to the treatable neovascular (wet)...
5.
Cai X, Chen L, McGinnis J
Exp Eye Res
. 2015 Sep;
140:130-138.
PMID: 26325328
Mutation of the Tub gene results in the mislocalization of photoreceptor-specific proteins and eventually retinal degeneration. However, the exact mechanism underlying the retinal degeneration remains largely unknown. In this study,...
6.
Walkey C, Das S, Seal S, Erlichman J, Heckman K, Ghibelli L, et al.
Environ Sci Nano
. 2015 Jul;
2(1):33-53.
PMID: 26207185
Cerium oxide nanoparticles (Nanoceria) have shown promise as catalytic antioxidants in the test tube, cell culture models and animal models of disease. However given the reactivity that is well established...
7.
Wong L, Pye Q, Chen L, Seal S, McGinnis J
PLoS One
. 2015 Mar;
10(3):e0121977.
PMID: 25822196
Purpose: Inorganic catalytic nanoceria or cerium oxide nanoparticles (CeNPs) are bona fide antioxidants that possess regenerative radical scavenging activities in vitro. Previously, we demonstrated that CeNPs had neuroprotective and anti-angiogenic...
8.
Cai X, Yodoi J, Seal S, McGinnis J
Adv Exp Med Biol
. 2014 Mar;
801:829-36.
PMID: 24664777
Oxidative stress is a node common to the causes and effects of various ocular diseases. We have shown that thioredoxin has neuroprotective effects on tubby photoreceptors. We also demonstrated that...
9.
Wong L, McGinnis J
Adv Exp Med Biol
. 2014 Mar;
801:821-8.
PMID: 24664776
Cerium oxide (CeO2) nanoparticles, CeNPs or nanoceria are inorganic and possess catalytic antioxidant activity. They scavenge reactive oxygen species and act as an oxygen buffer. Their application in industry is...
10.
Klump K, McGinnis J
Adv Exp Med Biol
. 2014 Mar;
801:655-9.
PMID: 24664755
Increased production of reactive oxygen species (ROS) is an attribute of malignant cells and is linked to the development of many of the characteristics considered "hallmarks of cancer (Hanahan and...