James Cloyd
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Explore the profile of James Cloyd including associated specialties, affiliations and a list of published articles.
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21
Citations
416
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Recent Articles
1.
Ahmed M, Krishna R, Rayad N, Albusaysi S, Mitra A, Shang E, et al.
Clin Pharmacol Ther
. 2024 Aug;
116(6):1412-1432.
PMID: 39148459
In the relentless pursuit of optimizing drug development, the intricate process of determining the ideal dosage unfolds. This involves "dose-finding" studies, crucial for providing insights into subsequent registration trials. However,...
2.
Pina-Garza J, Chez M, Cloyd J, Hirsch L, Kalviainen R, Klein P, et al.
Epileptic Disord
. 2024 May;
26(4):484-497.
PMID: 38813941
Objective: The management of prolonged seizures (PS) and seizure clusters (SC) is impeded by the lack of international, evidence-based guidance. We aimed to develop expert recommendations regarding consensus definitions of...
3.
Cloyd J, Pipkin J, Sen D
Epilepsy Behav
. 2023 Jul;
145:109314.
PMID: 37442737
No abstract available.
4.
Coles L, Rosenthal E, Bleck T, Elm J, Zehtabchi S, Chamberlain J, et al.
Epilepsy Behav
. 2023 Jan;
141:109066.
PMID: 36609129
We present the rationale for testing ketamine as an add-on therapy for treating benzodiazepine refractory (established) status epilepticus. In animal studies, ketamine terminates benzodiazepine refractory status epilepticus by interfering with...
5.
Schmitz N, Artz M, Walsh K, Gaudana S, Cloyd J, Schrogie J, et al.
Drugs Real World Outcomes
. 2022 Mar;
9(2):307-314.
PMID: 35357690
Background: Baclofen is an effective treatment for spasticity. Abrupt cessation of intrathecal (IT) or oral baclofen risks the development of withdrawal symptoms; however, the magnitude of the problem is unknown....
6.
Cloyd J, Haut S, Carrazana E, Rabinowicz A
Epilepsia
. 2021 Feb;
62(4):846-856.
PMID: 33617690
Seizure clusters must be treated quickly and effectively to prevent progression to prolonged seizures and status epilepticus. Rescue therapy for seizure clusters has focused on the use of benzodiazepines. Although...
7.
Chamberlain J, Kapur J, Shinnar S, Elm J, Holsti M, Babcock L, et al.
Lancet
. 2020 Mar;
395(10231):1217-1224.
PMID: 32203691
Background: Benzodiazepine-refractory, or established, status epilepticus is thought to be of similar pathophysiology in children and adults, but differences in underlying aetiology and pharmacodynamics might differentially affect response to therapy....
8.
Sathe A, Tuite P, Chen C, Ma Y, Chen W, Cloyd J, et al.
J Clin Pharmacol
. 2020 Feb;
60(6):744-750.
PMID: 32052462
Mitochondrial dysfunction is implicated in the pathogenesis of Parkinson's disease. Preliminary data have shown lower brain adenosine triphosphate (ATP) levels in Parkinson's disease versus age-matched healthy controls. Ursodeoxycholic acid (UDCA)...
9.
Kapur J, Elm J, Chamberlain J, Barsan W, Cloyd J, Lowenstein D, et al.
N Engl J Med
. 2019 Nov;
381(22):2103-2113.
PMID: 31774955
Background: The choice of drugs for patients with status epilepticus that is refractory to treatment with benzodiazepines has not been thoroughly studied. Methods: In a randomized, blinded, adaptive trial, we...
10.
Clark A, Pellock J, Holmay M, Anders B, Cloyd J
Epilepsy Behav
. 2016 Mar;
57(Pt A):105-110.
PMID: 26943947
Objective: The objectives of these two studies were to determine if beads from extended-release topiramate capsules sprinkled onto soft food are bioequivalent to the intact capsule and if beads from...