James C Engert
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Explore the profile of James C Engert including associated specialties, affiliations and a list of published articles.
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94
Citations
5625
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Recent Articles
1.
Riglea T, Dessy T, Kalubi J, Goulet D, Ikwa Ndol Mbutiwi F, Williams S, et al.
J Hum Hypertens
. 2025 Mar;
PMID: 40089570
Genome-wide association studies (GWAS) in adults have identified single nucleotide polymorphisms (SNPs) associated with systolic blood pressure (SBP), but it is unclear whether the findings apply in youth. Further, the...
2.
Bortnick A, Austin T, Hamerton E, Gudmundsdottir V, Emilsson V, Jennings L, et al.
J Am Heart Assoc
. 2025 Feb;
14(5):e036336.
PMID: 40008515
Background: Calcific aortic valve disease (CAVD), and ensuing severe aortic stenosis (AS), is the foremost valvular disorder of aging, yet preventive therapies are lacking. A better understanding of the molecular...
3.
Trenkwalder T, Maj C, Al-Kassou B, Debiec R, Doppler S, Musameh M, et al.
JAMA Cardiol
. 2024 Nov;
10(2):145-154.
PMID: 39504041
Importance: Aortic stenosis (AS) and coronary artery disease (CAD) frequently coexist. However, it is unknown which genetic and cardiovascular risk factors might be AS-specific and which could be shared between...
4.
Yang T, Small A, Dufresne L, Peloso G, Natarajan P, Engert J, et al.
J Am Coll Cardiol
. 2024 Jul;
84(6):592-594.
PMID: 39084832
No abstract available.
5.
Debban C, Ambalavanan A, Ghosh A, Li Z, Buschur K, Ma Y, et al.
Am J Respir Crit Care Med
. 2024 Jun;
210(12):1421-1431.
PMID: 38935874
Dysanapsis refers to a mismatch between airway tree caliber and lung size arising early in life. Dysanapsis assessed by computed tomography (CT) is evident by early adulthood and associated with...
6.
Suzuki K, Hatzikotoulas K, Southam L, Taylor H, Yin X, Lorenz K, et al.
Nature
. 2024 Feb;
627(8003):347-357.
PMID: 38374256
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution...
7.
Shelbaya K, Arthur V, Yang Y, Dorbala P, Buckley L, Claggett B, et al.
J Am Coll Cardiol
. 2024 Jan;
83(5):577-591.
PMID: 38296402
Background: Limited data exist regarding risk factors for aortic stenosis (AS). The plasma proteome is a promising phenotype for discovery of novel biomarkers and potentially causative mechanisms. Objectives: The aim...
8.
Rogers M, Bartoli-Leonard F, Zheng K, Small A, Chen H, Clift C, et al.
Circulation
. 2023 Nov;
149(5):391-401.
PMID: 37937463
Background: High circulating levels of Lp(a) (lipoprotein[a]) increase the risk of atherosclerosis and calcific aortic valve disease, affecting millions of patients worldwide. Although atherosclerosis is commonly treated with low-density lipoprotein-targeting...
9.
Shokoples B, Berillo O, Comeau K, Chen H, Higaki A, Caillon A, et al.
J Hypertens
. 2023 Oct;
41(11):1701-1712.
PMID: 37796207
Objective: Extracellular ATP is elevated in hypertensive mice and humans and may trigger immune activation through the purinergic receptor P2X7 (P2RX7) causing interleukin-1β production and T-cell activation and memory T-cell...
10.
Chen H, Dina C, Small A, Shaffer C, Levinson R, Helgadottir A, et al.
Eur Heart J
. 2023 Apr;
44(21):1927-1939.
PMID: 37038246
Aims: Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to...