James C Dodge
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Explore the profile of James C Dodge including associated specialties, affiliations and a list of published articles.
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36
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1274
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Recent Articles
1.
McInnis J, Sood D, Guo L, Dufault M, Garcia M, Passaro R, et al.
Commun Biol
. 2024 Nov;
7(1):1597.
PMID: 39616264
Ceramides are lipids that play vital roles in complex lipid synthesis, membrane function, and cell signaling. Disrupted ceramide homeostasis is implicated in cell-death and several neurologic diseases. Ceramides are often...
2.
Jagielska A, Radzwill K, Espinosa-Hoyos D, Yang M, Kowsari K, Farley J, et al.
Sci Rep
. 2023 Nov;
13(1):19529.
PMID: 37945646
Multiple sclerosis (MS), a chronic neurodegenerative disease driven by damage to the protective myelin sheath, is currently incurable. Today, all clinically available treatments modulate the immune-mediated symptoms of the disease...
3.
Li W, Berlinicke C, Huang Y, Giera S, McGrath A, Fang W, et al.
iScience
. 2023 Feb;
26(3):106156.
PMID: 36852281
Promoting myelination capacity of endogenous oligodendrocyte precursor cells (OPCs) is a promising therapeutic approach for CNS demyelinating disorders such as Multiple Sclerosis (MS). To aid in the discovery of myelination-promoting...
4.
Ryan S, Zelic M, Han Y, Teeple E, Chen L, Sadeghi M, et al.
Nat Neurosci
. 2022 Dec;
26(1):12-26.
PMID: 36536241
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain regions, but how iron accumulation influences microglia physiology and...
5.
Dodge J, Tamsett T, Treleaven C, Taksir T, Piepenhagen P, Sardi S, et al.
Alzheimers Res Ther
. 2022 Feb;
14(1):19.
PMID: 35105352
Background: Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is...
6.
Dodge J, Yu J, Sardi S, Shihabuddin L
Sci Rep
. 2021 Jan;
11(1):803.
PMID: 33436868
Aberrant cholesterol homeostasis is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disease that is due to motor neuron (MN) death. Cellular toxicity from excess cholesterol...
7.
Dodge J, Jensen E, Yu J, Sardi S, Bialas A, Taksir T, et al.
J Neurosci
. 2020 Oct;
40(47):9137-9147.
PMID: 33051352
Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease characterized by motor neuron (MN) death. Lipid dysregulation manifests during disease; however, it is unclear whether lipid homeostasis is adversely affected...
8.
Dodge J
Front Mol Neurosci
. 2017 Nov;
10:356.
PMID: 29163032
Lysosomal storage diseases (LSDs) are a heterogeneous group of rare inherited metabolic diseases that are frequently triggered by the accumulation of lipids inside organelles of the endosomal-autophagic-lysosomal system (EALS). There...
9.
Sardi S, Viel C, Clarke J, Treleaven C, Richards A, Park H, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(10):2699-2704.
PMID: 28223512
Mutations in the glucocerebrosidase gene () confer a heightened risk of developing Parkinson's disease (PD) and other synucleinopathies, resulting in a lower age of onset and exacerbating disease progression. However,...
10.
Rockenstein E, Clarke J, Viel C, Panarello N, Treleaven C, Kim C, et al.
Hum Mol Genet
. 2016 Apr;
25(13):2645-2660.
PMID: 27126635
Mutations in GBA1, the gene encoding glucocerebrosidase, are associated with an enhanced risk of developing synucleinopathies such as Parkinson's disease (PD) and dementia with Lewy bodies. A higher prevalence and...