James C Barrow
Overview
Explore the profile of James C Barrow including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
65
Citations
998
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Poslusney M, Ernst G, Huang Y, Gerlach A, Chapman M, Santos S, et al.
Bioorg Med Chem Lett
. 2024 Dec;
117():130059.
PMID: 39644938
The voltage-gated sodium channel Na1.8 (SCN10A) has strong genetic and pharmacological validation as a potential target for treating acute and chronic pain. While several different chemotypes have been advanced as...
2.
Fan W, Liu H, Stachelek G, Begum A, Davis C, Dorado T, et al.
bioRxiv
. 2024 Aug;
PMID: 39211199
Ribosome biosynthesis is a cancer vulnerability executed by targeting RNA polymerase I (Pol I) transcription. We developed advanced, specific Pol I inhibitors to identify drivers of this sensitivity. By integrating...
3.
Heitmann T, Liao G, Ernst G, Poslusney M, van Kralingen T, Li Y, et al.
J Med Chem
. 2024 Aug;
67(16):13639-13665.
PMID: 39096294
Inositol hexakisphosphate kinases (IP6Ks) have been studied for their role in glucose homeostasis, metabolic disease, fatty liver disease, chronic kidney disease, neurological development, and psychiatric disease. IP6Ks phosphorylate inositol hexakisphosphate...
4.
Heitmann T, Liao G, de Leon P, Ernst G, Buchler I, Wei H, et al.
ACS Med Chem Lett
. 2023 Dec;
14(12):1760-1766.
PMID: 38116421
A high-throughput fragment-based screen has been employed to discover a series of quinazolinone inositol hexakisphosphate kinase (IP6K) inhibitors. IP6Ks have been studied for their role in glucose homeostasis, metabolic disease,...
5.
Heitmann T, Barrow J
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759717
Inositol is a unique biological small molecule that can be phosphorylated or even further pyrophosphorylated on each of its six hydroxyl groups. These numerous phosphorylation states of inositol along with...
6.
DeBrosse A, Li Y, Wiseman R, Ross R, Garrison S, Hallock H, et al.
Behav Processes
. 2023 Sep;
212:104941.
PMID: 37673291
Attention is a cognitive domain often disrupted in neuropsychiatric disorders and continuous performance tests (CPTs) are common clinical assays of attention. In CPTs, participants produce a behavioral response to target...
7.
Mukherjee S, Chakraborty M, Haubner J, Ernst G, DePasquale M, Carpenter D, et al.
Biomolecules
. 2023 May;
13(5).
PMID: 37238737
Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus, drugs for the long-term treatment of these diseases are urgently needed. We previously discovered that the inositol...
8.
9.
Dorado T, de Leon P, Begum A, Liu H, Chen D, Rajeshkumar N, et al.
ACS Med Chem Lett
. 2022 Apr;
13(4):608-614.
PMID: 35450366
RNA polymerase I (Pol I) transcribes ribosomal DNA (rDNA) into the 47S ribosomal RNA (rRNA) precursor. Further processing produces the 28S, 5.8S, and 18S rRNAs that are assembled into mature...
10.
Noback M, Zhang G, White N, Barrow J, Carr G
Neurosci Lett
. 2020 Oct;
740:135423.
PMID: 33069811
Social isolation is a growing public health concern across the lifespan. Specifically, isolation early in life, during critical periods of brain development, increases the risk of psychiatric disorders later in...