James B Jaynes
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Explore the profile of James B Jaynes including associated specialties, affiliations and a list of published articles.
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29
Citations
1117
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Recent Articles
1.
Fujioka M, Ke W, Schedl P, Jaynes J
Genetics
. 2025 Feb;
PMID: 39999387
Chromatin insulators are major determinants of chromosome architecture. Specific architectures induced by insulators profoundly influence nuclear processes, including how enhancers and promoters interact over long distances and between homologous chromosomes....
2.
Fujioka M, Ke W, Schedl P, Jaynes J
bioRxiv
. 2025 Feb;
PMID: 39896478
Chromatin insulators are major determinants of chromosome architecture. Specific architectures induced by insulators profoundly influence nuclear processes, including how enhancers and promoters interact over long distances and between homologous chromosomes....
3.
Bing X, Ke W, Fujioka M, Kurbidaeva A, Levitt S, Levine M, et al.
Elife
. 2024 Aug;
13.
PMID: 39110499
Two different models have been proposed to explain how the endpoints of chromatin looped domains ('TADs') in eukaryotic chromosomes are determined. In the first, a cohesin complex extrudes a loop...
4.
Ke W, Fujioka M, Schedl P, Jaynes J
Elife
. 2024 Aug;
13.
PMID: 39110491
The chromosomes in multicellular eukaryotes are organized into a series of topologically independent loops called TADs. In flies, TADs are formed by physical interactions between neighboring boundaries. Fly boundaries exhibit...
5.
Rappaport J, Entezari A, Caspi A, Caksa S, Jhaveri A, Stanek T, et al.
Cell Mol Gastroenterol Hepatol
. 2021 Dec;
13(4):1276-1296.
PMID: 34954189
Background & Aims: Sporadic colorectal cancers arise from initiating mutations in APC, producing oncogenic β-catenin/TCF-dependent transcriptional reprogramming. Similarly, the tumor suppressor axis regulated by the intestinal epithelial receptor GUCY2C is...
6.
Guerrero-Santoro J, Khor J, Acikbas A, Jaynes J, Ettensohn C
J Biol Chem
. 2021 Jun;
297(1):100901.
PMID: 34157281
Alx1, a homeodomain-containing transcription factor, is a highly conserved regulator of skeletogenesis in echinoderms. In sea urchins, Alx1 plays a central role in the differentiation of embryonic primary mesenchyme cells...
7.
Fujioka M, Nezdyur A, Jaynes J
PLoS Genet
. 2021 Apr;
17(4):e1009536.
PMID: 33901190
Several distinct activities and functions have been described for chromatin insulators, which separate genes along chromosomes into functional units. Here, we describe a novel mechanism of functional separation whereby an...
8.
De S, Gehred N, Fujioka M, Chan F, Jaynes J, Kassis J
Genetics
. 2020 Sep;
216(3):689-700.
PMID: 32948625
Polycomb group (PcG) proteins are an important group of transcriptional repressors that act by modifying chromatin. PcG target genes are covered by the repressive chromatin mark H3K27me3. Polycomb repressive complex...
9.
Chen H, Levo M, Barinov L, Fujioka M, Jaynes J, Gregor T
Nat Genet
. 2018 Jul;
50(9):1296-1303.
PMID: 30038397
A long-standing question in gene regulation is how remote enhancers communicate with their target promoters, and specifically how chromatin topology dynamically relates to gene activation. Here, we combine genome editing...
10.
Peacock J, Jaynes J
Biochim Biophys Acta Gen Subj
. 2017 Aug;
1861(11 Pt A):2789-2801.
PMID: 28774855
Background: The affinities of DNA binding proteins for target sites can be used to model the regulation of gene expression. These proteins can bind to DNA cooperatively, strongly impacting their...