James A Oo
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Explore the profile of James A Oo including associated specialties, affiliations and a list of published articles.
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19
Citations
190
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Recent Articles
1.
Oo J, Warwick T, Palfi K, Lam F, McNicoll F, Prieto-Garcia C, et al.
Nat Commun
. 2025 Jan;
16(1):131.
PMID: 39747144
The coordination of chromatin remodeling is essential for DNA accessibility and gene expression control. The highly conserved and ubiquitously expressed SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex plays a central role...
2.
Prieto-Garcia C, Matkovic V, Mosler T, Li C, Liang J, Oo J, et al.
Science
. 2024 Nov;
386(6723):768-776.
PMID: 39541449
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanisms and cellular responses remain...
3.
Weiss L, Warwick T, Zehr S, Gunther S, Wolf S, Schmachtel T, et al.
Commun Biol
. 2024 Sep;
7(1):1131.
PMID: 39271940
Monocytes, the circulating macrophage precursors, contribute to diseases like atherosclerosis and asthma. Long non-coding RNAs (lncRNAs) have been shown to modulate the phenotype and inflammatory capacity of monocytes. We previously...
4.
Hu J, Leisegang M, Looso M, Drekolia M, Wittig J, Mettner J, et al.
Circ Res
. 2023 Oct;
133(10):842-857.
PMID: 37800327
Background: Advanced age is unequivocally linked to the development of cardiovascular disease; however, the mechanisms resulting in reduced endothelial cell regeneration remain poorly understood. Here, we investigated novel mechanisms involved...
5.
Boos F, Oo J, Warwick T, Gunther S, Izquierdo Ponce J, Lopez M, et al.
Basic Res Cardiol
. 2023 Jan;
118(1):5.
PMID: 36700983
Long non-coding RNAs (lncRNAs) can act as regulatory RNAs which, by altering the expression of target genes, impact on the cellular phenotype and cardiovascular disease development. Endothelial lncRNAs and their...
6.
Oo J, Palfi K, Warwick T, Wittig I, Prieto-Garcia C, Matkovic V, et al.
Cell Rep
. 2022 Nov;
41(7):111670.
PMID: 36384122
In healthy vessels, endothelial cells maintain a stable, differentiated, and growth-arrested phenotype for years. Upon injury, a rapid phenotypic switch facilitates proliferation to restore tissue perfusion. Here we report the...
7.
Leisegang M, Bains J, Seredinski S, Oo J, Krause N, Kuo C, et al.
Nat Commun
. 2022 Nov;
13(1):6563.
PMID: 36323673
DNA:DNA:RNA triplexes that are formed through Hoogsteen base-pairing of the RNA in the major groove of the DNA duplex have been observed in vitro, but the extent to which these...
8.
Warwick T, Seredinski S, Krause N, Bains J, Althaus L, Oo J, et al.
Brief Bioinform
. 2022 Oct;
23(6).
PMID: 36239395
RNA.DNA:DNA triple helix (triplex) formation is a form of RNA-DNA interaction which regulates gene expression but is difficult to study experimentally in vivo. This makes accurate computational prediction of such...
9.
Williams J, Huesa C, Turunen M, Oo J, Radzins O, Gardner W, et al.
J Musculoskelet Neuronal Interact
. 2022 Jun;
22(2):212-234.
PMID: 35642701
Objective: Characterise the spatiotemporal trabecular and cortical bone responses to complete spinal cord injury (SCI) in young rats. Methods: 8-week-old male Wistar rats received T9-transection SCI and were euthanised 2-,...
10.
Seredinski S, Boos F, Gunther S, Oo J, Warwick T, Izquierdo Ponce J, et al.
Mol Ther Nucleic Acids
. 2022 Mar;
27:1023-1035.
PMID: 35228897
The transcription factor hypoxia-inducible factor 1 (HIF1) is an important driver of cancer and is therefore an attractive drug target. Acriflavine (ACF) has been suggested to inhibit HIF1, but its...