James A Hoch
Overview
Explore the profile of James A Hoch including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
43
Citations
1542
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Hoch J
Annu Rev Microbiol
. 2017 Sep;
71:1-19.
PMID: 28886686
This is a tale of how technology drove the discovery of the molecular basis for signal transduction in the initiation of sporulation in Bacillus subtilis and in bacterial two-component systems....
2.
Bobay B, Hoch J, Cavanagh J
Biomol Concepts
. 2014 Feb;
3(2):175-182.
PMID: 24494032
Two-component signal transduction systems of microbes are a primary means to respond to signals emanating from environmental and metabolic fluctuations as well as to signals coordinating the cell cycle with...
3.
Yang H, Yung M, Li L, Hoch J, Ryan C, Kar U, et al.
DNA Repair (Amst)
. 2013 Mar;
12(5):334-46.
PMID: 23491602
The most important system for correcting replication errors that survive the built in editing system of DNA polymerase is the mismatch repair (MMR) system. We have identified a novel mutator...
4.
Szurmant H, Hoch J
Mol Microbiol
. 2013 Jan;
87(4):707-12.
PMID: 23279101
Statistical analyses of genome sequence-derived protein sequence data can identify amino acid residues that interact between proteins or between domains of a protein. These statistical methods are based on evolution-directed...
5.
Dago A, Schug A, Procaccini A, Hoch J, Weigt M, Szurmant H
Proc Natl Acad Sci U S A
. 2012 Jun;
109(26):E1733-42.
PMID: 22670053
Signal transduction proteins such as bacterial sensor histidine kinases, designed to transition between multiple conformations, are often ruled by unstable transient interactions making structural characterization of all functional states difficult....
6.
Steiner E, Dago A, Young D, Heap J, Minton N, Hoch J, et al.
Mol Microbiol
. 2011 Mar;
80(3):641-54.
PMID: 21401736
The phosphorylated Spo0A transcription factor controls the initiation of endospore formation in Clostridium acetobutylicum, but genes encoding key phosphorelay components, Spo0F and Spo0B, are missing in the genome. We hypothesized...
7.
Fukushima T, Furihata I, Emmins R, Daniel R, Hoch J, Szurmant H
Mol Microbiol
. 2011 Jan;
79(2):503-22.
PMID: 21219466
The YycG sensor histidine kinase co-ordinates cell wall remodelling with cell division in Gram-positive bacteria by controlling the transcription of genes for autolysins and their inhibitors. Bacillus subtilis YycG senses...
8.
Schug A, Weigt M, Hoch J, Onuchic J, Hwa T, Szurmant H
Methods Enzymol
. 2010 Oct;
471:43-58.
PMID: 20946841
Two-component signal transduction systems enable cells in bacteria, fungi, and plants to react to extracellular stimuli. A sensor histidine kinase (SK) detects such stimuli with its sensor domains and transduces...
9.
Lunt B, Szurmant H, Procaccini A, Hoch J, Hwa T, Weigt M
Methods Enzymol
. 2010 Oct;
471:17-41.
PMID: 20946840
Since the onset of the genomic era more than 1000 bacterial genomes have been sequenced and several fold more are expected to be completed in the near future. These genome...
10.
Bobay B, Thompson R, Hoch J, Cavanagh J
FEBS Lett
. 2010 Sep;
584(19):4203-7.
PMID: 20828564
When a point-mutation in a protein elicits a functional change, it is most common to assign this change to local structural perturbations. Here we show that point-mutations, distant from an...