James A Cornwell
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Explore the profile of James A Cornwell including associated specialties, affiliations and a list of published articles.
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11
Citations
59
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Recent Articles
1.
Saykali B, Tran A, Cornwell J, Caldwell M, Rezvan Sangsari P, Morgan N, et al.
bioRxiv
. 2024 Oct;
PMID: 39372752
Cyclin-dependent kinases (CDK) are key regulatory enzymes that regulate proliferation dynamics and cell fate in response to extracellular inputs. It remains largely unknown how CDK activity fluctuates and influences cell...
2.
Cornwell J, Crncec A, Afifi M, Tang K, Amin R, Cappell S
Nature
. 2024 Jun;
630(8018):E14.
PMID: 38858546
No abstract available.
3.
Lang F, Cornwell J, Kaur K, Elmogazy O, Zhang W, Zhang M, et al.
Neuro Oncol
. 2023 Dec;
26(6):1083-1096.
PMID: 38134889
Background: The cell cycle is tightly regulated by checkpoints, which play a vital role in controlling its progression and timing. Cancer cells exploit the G2/M checkpoint, which serves as a...
4.
Zong D, Koussa N, Cornwell J, Pankajam A, Kruhlak M, Wong N, et al.
Genes Dev
. 2023 Nov;
37(19-20):913-928.
PMID: 37932011
Addiction to the WRN helicase is a unique vulnerability of human cancers with high levels of microsatellite instability (MSI-H). However, while prolonged loss of WRN ultimately leads to cell death,...
5.
Zong D, Koussa N, Cornwell J, Pankajam A, Kruhlak M, Wong N, et al.
bioRxiv
. 2023 Sep;
PMID: 37662356
Addiction to the WRN helicase is a unique vulnerability of human cancers with high levels of microsatellite instability (MSI-H). However, while prolonged loss of WRN ultimately leads to cell death,...
6.
Afifi M, Crncec A, Cornwell J, Cataisson C, Paul D, Ghorab L, et al.
Cell Rep
. 2023 Sep;
42(9):113079.
PMID: 37656618
Cells can irreversibly exit the cell cycle and become senescent to safeguard against uncontrolled proliferation. While the p53-p21 and p16-Rb pathways are thought to mediate senescence, they also mediate reversible...
7.
Cornwell J, Crncec A, Afifi M, Tang K, Amin R, Cappell S
Nature
. 2023 Jul;
619(7969):363-370.
PMID: 37407814
In mammalian cells, the decision to proliferate is thought to be irreversibly made at the restriction point of the cell cycle, when mitogen signalling engages a positive feedback loop between...
8.
Paul D, Kales S, Cornwell J, Afifi M, Rai G, Zakharov A, et al.
Nat Commun
. 2022 Oct;
13(1):6364.
PMID: 36289220
The F-box protein beta-transducin repeat containing protein (β-TrCP) acts as a substrate adapter for the SCF E3 ubiquitin ligase complex, plays a crucial role in cell physiology, and is often...
9.
Mahadevan S, Cornwell J, Chami B, Kelly E, Zoellner H
Biomolecules
. 2021 Dec;
11(12).
PMID: 34944519
We earlier reported that cell-projection pumping transfers fibroblast contents to cancer cells and this alters the cancer cell phenotype. Here, we report on single-cell tracking of time lapse recordings from...
10.
Nathans J, Cornwell J, Afifi M, Paul D, Cappell S
Sci Adv
. 2021 Feb;
7(3).
PMID: 33523889
The G-S checkpoint is thought to prevent cells with damaged DNA from entering S phase and replicating their DNA and efficiently arrests cells at the G-S transition. Here, using time-lapse...