Jakob S Pedersen
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Explore the profile of Jakob S Pedersen including associated specialties, affiliations and a list of published articles.
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18
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8796
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Recent Articles
1.
Rasmussen A, Okholm T, Knudsen M, Vang S, Dyrskjot L, Hansen T, et al.
NAR Cancer
. 2023 Aug;
5(3):zcad041.
PMID: 37554968
Until recently, intronic lariats were regarded as short-lasting splicing byproducts with no apparent function; however, increasing evidence of stable derivatives suggests regulatory roles. Yet little is known about their characteristics,...
2.
Henriksen T, Drue S, Frydendahl A, Demuth C, Rasmussen M, Reinert T, et al.
Clin Chem
. 2022 Jan;
68(5):657-667.
PMID: 35030248
Background: Droplet digital PCR (ddPCR) is a widely used and sensitive application for circulating tumor DNA (ctDNA) detection. As ctDNA is often found in low abundance, methods to separate low-signal...
3.
Strand S, Switnicki M, Moller M, Haldrup C, Storebjerg T, Hedegaard J, et al.
Oncotarget
. 2017 Jan;
8(4):5774-5788.
PMID: 28052017
Purpose: The lack of biomarkers that can distinguish aggressive from indolent prostate cancer has caused substantial overtreatment of clinically insignificant disease. Here, by genome-wide DNA methylome profiling, we sought to...
4.
Christensen L, True K, Hamilton M, Nielsen M, Damas N, Damgaard C, et al.
Mol Oncol
. 2016 Jul;
10(8):1266-82.
PMID: 27396952
It is well established that lncRNAs are aberrantly expressed in cancer where they have been shown to act as oncogenes or tumor suppressors. RNA profiling of 314 colorectal adenomas/adenocarcinomas and...
5.
Switnicki M, Juul M, Madsen T, Sorensen K, Pedersen J
Bioinformatics
. 2016 Jan;
32(9):1353-65.
PMID: 26740525
Motivation: Cancer development and progression is driven by a complex pattern of genomic and epigenomic perturbations. Both types of perturbations can affect gene expression levels and disease outcome. Integrative analysis...
6.
Montes M, Nielsen M, Maglieri G, Jacobsen A, Hojfeldt J, Agrawal-Singh S, et al.
Nat Commun
. 2015 Apr;
6:6967.
PMID: 25908244
Oncogene-induced senescence (OIS) can occur in response to oncogenic insults and is considered an important tumour suppressor mechanism. Here we identify the lncRNA MIR31HG as upregulated in OIS and find...
7.
Reinert T, Scholer L, Thomsen R, Tobiasen H, Vang S, Nordentoft I, et al.
Gut
. 2015 Feb;
65(4):625-34.
PMID: 25654990
Objective: To develop an affordable and robust pipeline for selection of patient-specific somatic structural variants (SSVs) being informative about radicality of the primary resection, response to adjuvant therapy, incipient recurrence...
8.
Stampe Ostenfeld M, Jeppesen D, Laurberg J, Boysen A, Bramsen J, Primdal-Bengtson B, et al.
Cancer Res
. 2014 Sep;
74(20):5758-71.
PMID: 25261234
Exosomes are small secreted vesicles that can transfer their content to recipient cells. In cancer, exosome secretion has been implicated in tumor growth and metastatic spread. In this study, we...
9.
Lin M, Kheradpour P, Washietl S, Parker B, Pedersen J, Kellis M
Genome Res
. 2011 Oct;
21(11):1916-28.
PMID: 21994248
The degeneracy of the genetic code allows protein-coding DNA and RNA sequences to simultaneously encode additional, overlapping functional elements. A sequence in which both protein-coding and additional overlapping functions have...
10.
Lindblad-Toh K, Garber M, Zuk O, Lin M, Parker B, Washietl S, et al.
Nature
. 2011 Oct;
478(7370):476-82.
PMID: 21993624
The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at...