Jakob Loven
Overview
Explore the profile of Jakob Loven including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
3866
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Recent Articles
1.
McKeown M, Corces M, Eaton M, Fiore C, Lee E, Lopez J, et al.
Cancer Discov
. 2017 Jul;
7(10):1136-1153.
PMID: 28729405
We characterized the enhancer landscape of 66 patients with acute myeloid leukemia (AML), identifying 6 novel subgroups and their associated regulatory loci. These subgroups are defined by their superenhancer (SE)...
2.
Lohcharoenkal W, Harada M, Loven J, Meisgen F, Landen N, Zhang L, et al.
J Invest Dermatol
. 2016 Jul;
136(12):2485-2494.
PMID: 27452220
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer and a leading cause of cancer mortality among solid organ transplant recipients. MicroRNAs (miR) are short RNAs that regulate...
3.
Ribeiro D, Klarqvist M, Westermark U, Oliynyk G, Dzieran J, Kock A, et al.
Cell Rep
. 2016 Jul;
16(4):979-993.
PMID: 27396325
MYCN amplification and MYC signaling are associated with high-risk neuroblastoma with poor prognosis. Treating these tumors remains challenging, although therapeutic approaches stimulating differentiation have generated considerable interest. We have previously...
4.
Anders L, Guenther M, Qi J, Fan Z, Marineau J, Rahl P, et al.
Nat Biotechnol
. 2013 Dec;
32(1):92-6.
PMID: 24336317
A vast number of small-molecule ligands, including therapeutic drugs under development and in clinical use, elicit their effects by binding specific proteins associated with the genome. An ability to map...
5.
Li Y, Wang H, Muffat J, Cheng A, Orlando D, Loven J, et al.
Cell Stem Cell
. 2013 Oct;
13(4):446-58.
PMID: 24094325
Rett syndrome (RTT) is caused by mutations of MECP2, a methyl CpG binding protein thought to act as a global transcriptional repressor. Here we show, using an isogenic human embryonic...
6.
Loven J, Hoke H, Lin C, Lau A, Orlando D, Vakoc C, et al.
Cell
. 2013 Apr;
153(2):320-34.
PMID: 23582323
Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells. Here, we investigate how...
7.
Loven J, Orlando D, Sigova A, Lin C, Rahl P, Burge C, et al.
Cell
. 2012 Oct;
151(3):476-82.
PMID: 23101621
Gene expression analysis is a widely used and powerful method for investigating the transcriptional behavior of biological systems, for classifying cell states in disease, and for many other purposes. Recent...
8.
Lin C, Loven J, Rahl P, Paranal R, Burge C, Bradner J, et al.
Cell
. 2012 Oct;
151(1):56-67.
PMID: 23021215
Elevated expression of the c-Myc transcription factor occurs frequently in human cancers and is associated with tumor aggression and poor clinical outcome. The effect of high levels of c-Myc on...
9.
Mullen A, Orlando D, Newman J, Loven J, Kumar R, Bilodeau S, et al.
Cell
. 2011 Nov;
147(3):565-76.
PMID: 22036565
Transforming growth factor beta (TGF-β) signaling, mediated through the transcription factors Smad2 and Smad3 (Smad2/3), directs different responses in different cell types. Here we report that Smad3 co-occupies the genome...
10.
Frenzel A, Loven J, Henriksson M
Genes Cancer
. 2011 Jul;
1(6):660-7.
PMID: 21779463
The MYC protein controls many cellular processes, including proliferation, cell cycle progression, cell growth, metabolism, angiogenesis, differentiation, cell adhesion, and motility. This is primarily achieved through transcriptional regulation of large...