Jake Gagnon
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Explore the profile of Jake Gagnon including associated specialties, affiliations and a list of published articles.
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7
Citations
56
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Recent Articles
1.
Hu W, Li K, Gagnon J, Wang Y, Raney T, Chen J, et al.
Bioengineering (Basel)
. 2025 Jan;
12(1.
PMID: 39851331
Early-stage detection of neurodegenerative diseases is crucial for effective clinical treatment. However, current diagnostic methods are expensive and time-consuming. In this study, we present FundusNet, a deep-learning model trained on...
2.
Gadd D, Hillary R, Kuncheva Z, Mangelis T, Cheng Y, Dissanayake M, et al.
Nat Aging
. 2024 Jul;
4(7):939-948.
PMID: 38987645
The circulating proteome offers insights into the biological pathways that underlie disease. Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age-related diseases and mortality...
3.
Guise A, Misal S, Carson R, Chu J, Boekweg H, Van Der Watt D, et al.
Cell Rep
. 2024 Jan;
43(1):113636.
PMID: 38183652
A limitation of conventional bulk-tissue proteome studies in amyotrophic lateral sclerosis (ALS) is the confounding of motor neuron (MN) signals by admixed non-MN proteins. Here, we leverage laser capture microdissection...
4.
Tereshko L, Zhao X, Gagnon J, Lin T, Ewald T, Wang Y, et al.
PLoS One
. 2023 Dec;
18(12):e0293277.
PMID: 38096204
Recombinant adeno-associated virus (rAAV) vectors have become a reliable strategy for delivering gene therapies. As rAAV capsid content is known to be heterogeneous, methods for rAAV characterization are critical for...
5.
Guise A, Misal S, Carson R, Boekweg H, Van Der Watt D, Truong T, et al.
bioRxiv
. 2023 Jun;
PMID: 37333094
Unbiased proteomics has been employed to interrogate central nervous system (CNS) tissues (brain, spinal cord) and fluid matrices (CSF, plasma) from amyotrophic lateral sclerosis (ALS) patients; yet, a limitation of...
6.
Fogelman I, West T, Braunstein J, Verghese P, Kirmess K, Meyer M, et al.
Ann Clin Transl Neurol
. 2023 Mar;
10(5):765-778.
PMID: 36975407
Background: The amyloid probability score (APS) is the model read-out of the analytically validated mass spectrometry-based PrecivityAD blood test that incorporates the plasma Aβ42/40 ratio, ApoE proteotype, and age to...
7.
Gagnon J, Pi L, Ryals M, Wan Q, Hu W, Ouyang Z, et al.
Life (Basel)
. 2022 Jun;
12(6).
PMID: 35743881
To guide analysts to select the right tool and parameters in differential gene expression analyses of single-cell RNA sequencing (scRNA-seq) data, we developed a novel simulator that recapitulates the data...
8.
McAvoy K, Rajamohamed Sait H, Marsh G, Peterson M, Reynolds T, Gagnon J, et al.
PLoS One
. 2019 Aug;
14(8):e0220125.
PMID: 31408457
BIN1 is the most important risk locus for Late Onset Alzheimer's Disease (LOAD), after ApoE. BIN1 AD-associated SNPs correlate with Tau deposition as well as with brain atrophy. Furthermore, the...