Jaime Symowicz
Overview
Explore the profile of Jaime Symowicz including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
363
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0
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Recent Articles
1.
Wilson A, Bora C, Silva C, White J, Sanfratello N, Symowicz J, et al.
Chronic Obstr Pulm Dis
. 2024 Oct;
11(6):582-590.
PMID: 39361976
Rationale: Evidence-based guidelines recommend screening all individuals with chronic obstructive pulmonary disease (COPD) for the genetic disorder alpha-1 antitrypsin deficiency (AATD). However, it is estimated that only 5% of people...
2.
Liu Y, Burkhalter R, Symowicz J, Chaffin K, Ellerbroek S, Stack M
J Oncol
. 2012 May;
2012:501492.
PMID: 22593767
Ovarian cancer metastasizes via exfoliation of free-floating cells and multicellular aggregates from the primary tumor to the peritoneal cavity. A key event in EOC metastasis is disruption of cell-cell contacts...
3.
Burkhalter R, Symowicz J, Hudson L, Gottardi C, Stack M
J Biol Chem
. 2011 Apr;
286(26):23467-75.
PMID: 21518759
Reversible modulation of integrin-regulated cell-matrix adhesion and epithelial (E)-cadherin-mediated cell-cell adhesion plays a critical role in the establishment of ovarian cancer metastases. In contrast to most epithelial cell-derived tumors that...
4.
Woo M, Salamanca C, Symowicz J, Stack M, Miller D, Leung P, et al.
Gynecol Oncol
. 2008 Aug;
111(1):125-31.
PMID: 18678400
Objective: Serous borderline ovarian tumors (SBOT) are slow growing, noninvasive ovarian epithelial neoplasms, which tend to recur as low-grade invasive carcinomas (LGC) with a much worse prognosis. We investigated the...
5.
Cowden Dahl K, Symowicz J, Ning Y, Gutierrez E, Fishman D, Adley B, et al.
Cancer Res
. 2008 Jun;
68(12):4606-13.
PMID: 18559505
Epidermal growth factor (EGF) receptor (EGFR) is frequently elevated in epithelial ovarian cancer, and E-cadherin expression is often reduced in advanced disease. In this study, we investigated a mechanism by...
6.
Symowicz J, Adley B, Gleason K, Johnson J, Ghosh S, Fishman D, et al.
Cancer Res
. 2007 Mar;
67(5):2030-9.
PMID: 17332331
Reversible modulation of cell-cell adhesion, cell-matrix adhesion, and proteolytic activity plays a critical role in remodeling of the neoplastic ovarian epithelium during metastasis, implicating cadherins, integrins, and proteinases in i.p....
7.
Symowicz J, Adley B, Woo M, Auersperg N, Hudson L, Stack M
Cancer Res
. 2005 Mar;
65(6):2234-42.
PMID: 15781636
Elevated levels of the bioactive lipid lysophosphatidic acid (LPA) are detectable in the majority of patients with both early- and late-stage ovarian cancer, suggesting that LPA promotes early events in...
8.
Schroeder M, Symowicz J, Schuler L
Mol Endocrinol
. 2002 Jan;
16(1):45-57.
PMID: 11773438
PRL is essential for normal lobulo-alveolar growth of the mammary gland and may contribute to mammary cancer development or progression. However, analysis of the mechanism of action of PRL in...