Jaewon J Lee
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Explore the profile of Jaewon J Lee including associated specialties, affiliations and a list of published articles.
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12
Citations
278
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Recent Articles
1.
Lee J, Kearney J, Trembath H, Hariharan A, LaBella M, Kharitonova E, et al.
Ann Surg
. 2024 Jun;
280(4):659-666.
PMID: 38887930
Objective: To assess the utility of tumor-intrinsic and cancer-associated fibroblast (CAF) subtypes of pancreatic ductal adenocarcinoma (PDAC) in predicting response to neoadjuvant therapy (NAT) and overall survival (OS). Background: PDAC...
2.
Bahrambeigi V, Lee J, Branchi V, Rajapakshe K, Xu Z, Kui N, et al.
Cancer Res
. 2024 Mar;
84(10):1719-1732.
PMID: 38451249
Significance: The development of an approach to interrogate molecular subtypes, cancer-associated pathways, and differentially expressed genes through RNA sequencing of plasma extracellular vesicles lays the foundation for liquid biopsy-based longitudinal...
3.
Semaan A, Bernard V, Wong J, Makino Y, Swartzlander D, Rajapakshe K, et al.
Cancer Res Commun
. 2023 Sep;
3(10):2062-2073.
PMID: 37721516
Significance: Integrated molecular analysis of genomic and transcriptomic alterations in the multistep progression of IPMNs, which are bona fide precursors of pancreatic cancer, identifies features associated with progression of low-risk...
4.
Kolbinger F, Bernard V, Lee J, Stephens B, Branchi V, Raghav K, et al.
J Gastrointest Cancer
. 2023 Mar;
54(4):1276-1285.
PMID: 36862364
Purpose: Cancer of unknown primary (CUP) accounts for 2-5% of all cancer diagnoses, wherein standard investigations fail to reveal the original tumor site. Basket trials allocate targeted therapeutics based on...
5.
Monberg M, Geiger H, Lee J, Sharma R, Semaan A, Bernard V, et al.
Nat Commun
. 2022 Jun;
13(1):3652.
PMID: 35752636
Heterogeneity is a hallmark of cancer. The advent of single-cell technologies has helped uncover heterogeneity in a high-throughput manner in different cancers across varied contexts. Here we apply single-cell sequencing...
6.
Garcia Garcia C, Huang Y, Fuentes N, Turner M, Monberg M, Lin D, et al.
Gastroenterology
. 2022 Feb;
162(7):2018-2031.
PMID: 35216965
Background & Aims: Pancreatic ductal adenocarcinoma (PDAC) has a hypoxic, immunosuppressive stroma that contributes to its resistance to immune checkpoint blockade therapies. The hypoxia-inducible factors (HIFs) mediate the cellular response...
7.
Lee J, Bernard V, Semaan A, Monberg M, Huang J, Stephens B, et al.
Clin Cancer Res
. 2021 Aug;
27(21):5912-5921.
PMID: 34426439
Purpose: Precision medicine approaches in pancreatic ductal adenocarcinoma (PDAC) are imperative for improving disease outcomes. With molecular subtypes of PDAC gaining relevance in the context of therapeutic stratification, the ability...
8.
Semaan A, Bernard V, Kim D, Lee J, Huang J, Kamyabi N, et al.
Br J Cancer
. 2021 Mar;
124(12):1970-1977.
PMID: 33785875
Background: Limited accessibility of the tumour precludes longitudinal characterisation for therapy guidance in pancreatic ductal adenocarcinoma (PDAC). Methods: We utilised dielectrophoresis-field flow fractionation (DEP-FFF) to isolate circulating tumour cells (CTCs)...
9.
Semaan A, Bernard V, Lee J, Wong J, Huang J, Swartzlander D, et al.
Clin Cancer Res
. 2020 Nov;
27(4):1082-1093.
PMID: 33188144
Purpose: Most patients with pancreatic ductal adenocarcinoma (PDAC) present with surgically unresectable cancer. As a result, endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the most common biospecimen source available for diagnosis...
10.
Lee J, Kopetz S, Vilar E, Shen J, Chen K, Maitra A
Genes (Basel)
. 2020 Jun;
11(6).
PMID: 32545271
There is increasing evidence of gastrointestinal (GI) infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We surveyed the co-expression of SARS-CoV-2 entry genes and throughout the GI tract to...