Jae-Won Cho
Overview
Explore the profile of Jae-Won Cho including associated specialties, affiliations and a list of published articles.
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23
Citations
1353
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Recent Articles
1.
Lee J, Barnett S, Roberts K, Ashwin H, Milross L, Cho J, et al.
Nat Commun
. 2025 Mar;
16(1):1979.
PMID: 40064844
The most common cause of death due to COVID-19 remains respiratory failure. Yet, our understanding of the precise cellular and molecular changes underlying lung alveolar damage is limited. Here, we...
2.
Shiau C, Cao J, Gong D, Gregory M, Caldwell N, Yin X, et al.
Nat Genet
. 2024 Sep;
56(11):2466-2478.
PMID: 39227743
In combination with cell-intrinsic properties, interactions in the tumor microenvironment modulate therapeutic response. We leveraged single-cell spatial transcriptomics to dissect the remodeling of multicellular neighborhoods and cell-cell interactions in human...
3.
Cha J, Kim D, Kim G, Cho J, Sung E, Baek S, et al.
J Immunother Cancer
. 2024 Jun;
12(6).
PMID: 38857913
Background: Oropharyngeal squamous cell carcinoma (OPSCC) induced by human papillomavirus (HPV-positive) is associated with better clinical outcomes than HPV-negative OPSCC. However, the clinical benefits of immunotherapy in patients with HPV-positive...
4.
Cho J, Cao J, Hemberg M
Genome Biol
. 2024 Mar;
25(1):65.
PMID: 38459554
Background: Tumors are able to acquire new capabilities, including traits such as drug resistance and metastasis that are associated with unfavorable clinical outcomes. Single-cell technologies have made it possible to...
5.
Wang Y, Cho J, Kastrunes G, Buck A, Razimbaud C, Culhane A, et al.
iScience
. 2024 Feb;
27(2):108879.
PMID: 38327771
One of the major barriers that have restricted successful use of chimeric antigen receptor (CAR) T cells in the treatment of solid tumors is an unfavorable tumor microenvironment (TME). We...
6.
Shiau C, Cao J, Gregory M, Gong D, Yin X, Cho J, et al.
bioRxiv
. 2023 Jul;
PMID: 37425692
In combination with cell intrinsic properties, interactions in the tumor microenvironment modulate therapeutic response. We leveraged high-plex single-cell spatial transcriptomics to dissect the remodeling of multicellular neighborhoods and cell-cell interactions...
7.
Cha J, Yu J, Cho J, Hemberg M, Lee I
Nucleic Acids Res
. 2022 Nov;
51(2):e8.
PMID: 36350625
A major challenge in single-cell biology is identifying cell-type-specific gene functions, which may substantially improve precision medicine. Differential expression analysis of genes is a popular, yet insufficient approach, and complementary...
8.
Baldominos P, Barbera-Mourelle A, Barreiro O, Huang Y, Wight A, Cho J, et al.
Cell
. 2022 Apr;
185(10):1694-1708.e19.
PMID: 35447074
Immunotherapy is a promising treatment for triple-negative breast cancer (TNBC), but patients relapse, highlighting the need to understand the mechanisms of resistance. We discovered that in primary breast cancer, tumor...
9.
Cho J, Shim H, Lee C, Park S, Hong M, Lee I, et al.
Exp Mol Med
. 2022 Jan;
54(1):12-22.
PMID: 34987166
Lung squamous cell carcinoma (LUSC) is a subtype of non-small cell lung cancer (NSCLC). LUSC occurs at the bronchi, shows a squamous appearance, and often occurs in smokers. To determine...
10.
Cho J, Park S, Kim G, Han H, Shim H, Shin S, et al.
Nat Commun
. 2021 Oct;
12(1):6068.
PMID: 34663810
Patients with non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations exhibit an unfavorable response to PD-1 inhibitor through unclear mechanisms. Hypothesizing that EGFR mutations alter tumor-immune...