Jacques P Tremblay
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Explore the profile of Jacques P Tremblay including associated specialties, affiliations and a list of published articles.
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129
Citations
2407
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Recent Articles
21.
Happi Mbakam C, Lamothe G, Tremblay J
Front Med (Lausanne)
. 2022 Apr;
9:859930.
PMID: 35419381
Duchenne muscular dystrophy (DMD) is an X-linked hereditary disease characterized by progressive muscle wasting due to modifications in the gene (exon deletions, nonsense mutations, intra-exonic insertions or deletions, exon duplications,...
22.
Happi Mbakam C, Lamothe G, Tremblay G, Tremblay J
Neurotherapeutics
. 2022 Feb;
19(3):931-941.
PMID: 35165856
Discovery of the CRISPR-Cas (clustered regularly interspaced short palindromic repeat, CRISPR-associated) system a decade ago has opened new possibilities in the field of precision medicine. CRISPR-Cas was initially identified in...
23.
Tremblay G, Rousseau J, Happi Mbakam C, Tremblay J
CRISPR J
. 2022 Feb;
5(1):109-122.
PMID: 35133877
Alzheimer's disease (AD) is the result of abnormal processing of the amyloid precursor protein (APP) by β-secretase and γ-secretase, which leads to the formation of toxic β-amyloid peptides. The toxic...
24.
Yameogo P, Duchene B, Majeau N, Tremblay J
Gene Ther
. 2021 Oct;
29(3-4):171-177.
PMID: 34593991
CRISPR/Cas9 has paved the way for the development of therapies that correct genetic mutations. However, constitutive expression of the Cas9 gene can increase off-target mutations and induce an immune response...
25.
Guyon A, Rousseau J, Begin F, Bertin T, Lamothe G, Tremblay J
Mol Ther Nucleic Acids
. 2021 Apr;
24:253-263.
PMID: 33815938
The amyloid precursor protein () is a transmembrane protein mostly found in neurons. Cleavage of this protein by β-secretase can lead to the formation of amyloid-β (Aβ) peptide plaque, which...
26.
Tremblay J, Annoni A, Suzuki M
Mol Ther
. 2021 Jan;
29(2):411-412.
PMID: 33472032
No abstract available.
27.
Guyon A, Rousseau J, Lamothe G, Tremblay J
PLoS One
. 2020 Dec;
15(12):e0237122.
PMID: 33370284
The deposition of Aβ plaques in the brain leads to the onset and development of Alzheimer's disease. The Amyloid precursor protein (APP) is cleaved by α-secretase (non-amyloidogenic processing of APP),...
28.
Mendell J, Al-Zaidy S, Rodino-Klapac L, Goodspeed K, Gray S, Kay C, et al.
Mol Ther
. 2020 Dec;
29(2):464-488.
PMID: 33309881
Hereditary diseases are caused by mutations in genes, and more than 7,000 rare diseases affect over 30 million Americans. For more than 30 years, hundreds of researchers have maintained that...
29.
Skuk D, Tremblay J
J Neuropathol Exp Neurol
. 2020 Oct;
79(12):1265-1275.
PMID: 33094339
This study aimed to verify if human myogenic cells could participate in muscle regeneration in macaques. This experimental setting would grant researchers a model that could better evaluate the effects...
30.
Benabdallah B, Desaulniers-Langevin C, Goyer M, Colas C, Maltais C, Li Y, et al.
Stem Cells Transl Med
. 2020 Sep;
10(2):267-277.
PMID: 32881406
It is still unclear if immune responses will compromise the large-scale utilization of human induced pluripotent stem cells (hiPSCs)-derived cell therapies. To answer this question, we used humanized mouse models...