Jacquelyn L Nelson
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Explore the profile of Jacquelyn L Nelson including associated specialties, affiliations and a list of published articles.
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19
Citations
289
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Recent Articles
1.
Cohen R, Sosnicki D, White M, Nelson J, Mukai C, Travis A
J Vis Exp
. 2023 Oct;
(200).
PMID: 37902325
Acrosome exocytosis (AE), in which the sperm's single exocytotic vesicle fuses with the plasma membrane, is a complex, calcium-dependent process essential for fertilization. However, our understanding of how calcium signaling...
2.
Sosnicki D, Cohen R, Asano A, Nelson J, Mukai C, Comizzoli P, et al.
Biol Reprod
. 2023 Sep;
109(6):864-877.
PMID: 37694824
The murine epididymis has 10 distinct segments that provide the opportunity to identify compartmentalized cell physiological mechanisms underlying sperm maturation. However, despite the essential role of the epididymis in reproduction,...
3.
Cohen R, Mukai C, Nelson J, Zenilman S, Sosnicki D, Travis A
J Biol Chem
. 2022 Mar;
298(5):101868.
PMID: 35346690
Secretion of the acrosome, a single vesicle located rostrally in the head of a mammalian sperm, through a process known as "acrosome exocytosis" (AE), is essential for fertilization. However, the...
4.
Mukai C, Nelson J, Cheong S, Diel de Amorim M, Travis A
Theriogenology
. 2020 Feb;
150:347-352.
PMID: 32088047
Previously, we reported the first live births of dogs using in vitro fertilization (IVF), embryo cryopreservation, and transfer. These techniques have potential applications in the conservation of endangered canids, and...
5.
Asano A, Roman H, Hirschberger L, Ushiyama A, Nelson J, Hinchman M, et al.
FEBS J
. 2018 Apr;
285(10):1827-1839.
PMID: 29604178
Sperm entering the epididymis are immotile and cannot respond to stimuli that will enable them to fertilize. The epididymis is a highly complex organ, with multiple histological zones and cell...
6.
Mukai C, Gao L, Nelson J, Lata J, Cohen R, Wu L, et al.
Angew Chem Int Ed Engl
. 2016 Dec;
56(1):235-238.
PMID: 27901298
For nanobiotechnology to achieve its potential, complex organic-inorganic systems must grow to utilize the sequential functions of multiple biological components. Critical challenges exist: immobilizing enzymes can block substrate-binding sites or...
7.
Nagashima J, Sylvester S, Nelson J, Cheong S, Mukai C, Lambo C, et al.
PLoS One
. 2015 Dec;
10(12):e0143930.
PMID: 26650234
Development of assisted reproductive technologies (ART) in the dog has resisted progress for decades, due to their unique reproductive physiology. This lack of progress is remarkable given the critical role...
8.
Cohen R, Lata J, Lee Y, Cruz Hernandez J, Nishimura N, Schaffer C, et al.
PLoS One
. 2015 Nov;
10(11):e0142326.
PMID: 26605916
Background: Rapid diagnosis for time-sensitive illnesses such as stroke, cardiac arrest, and septic shock is essential for successful treatment. Much attention has therefore focused on new strategies for rapid and...
9.
Lata J, Gao L, Mukai C, Cohen R, Nelson J, Anguish L, et al.
Bioconjug Chem
. 2015 Aug;
26(9):1931-8.
PMID: 26280845
Despite numerous applications, we lack fundamental understanding of how variables such as nanoparticle (NP) size influence the activity of tethered enzymes. Previously, we showed that biomimetic oriented immobilization yielded higher...
10.
Cohen R, Buttke D, Asano A, Mukai C, Nelson J, Ren D, et al.
Dev Cell
. 2014 Feb;
28(3):310-21.
PMID: 24525187
Membrane lipid regulation of cell function is poorly understood. In early development, sterol efflux and the ganglioside GM1 regulate sperm acrosome exocytosis (AE) and fertilization competence through unknown mechanisms. Here,...