Jacqueline C M Witteman
Overview
Explore the profile of Jacqueline C M Witteman including associated specialties, affiliations and a list of published articles.
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28236
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Recent Articles
11.
Ganesh S, Chasman D, Larson M, Guo X, Verwoert G, Bis J, et al.
Am J Hum Genet
. 2014 Jul;
95(1):49-65.
PMID: 24975945
Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and susceptibility to measurement error. Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring...
12.
Simino J, Shi G, Bis J, Chasman D, Ehret G, Gu X, et al.
Am J Hum Genet
. 2014 Jun;
95(1):24-38.
PMID: 24954895
Although age-dependent effects on blood pressure (BP) have been reported, they have not been systematically investigated in large-scale genome-wide association studies (GWASs). We leveraged the infrastructure of three well-established consortia...
13.
Arking D, Pulit S, Crotti L, van der Harst P, Munroe P, Koopmann T, et al.
Nat Genet
. 2014 Jun;
46(8):826-36.
PMID: 24952745
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate...
14.
Versmissen J, Oosterveer D, Yazdanpanah M, Dehghan A, Holm H, Erdman J, et al.
Eur J Hum Genet
. 2014 Jun;
23(3):381-7.
PMID: 24916650
Mutations in the low-density lipoprotein receptor (LDLR) gene cause familial hypercholesterolemia (FH), a disorder characterized by coronary heart disease (CHD) at young age. We aimed to apply an extreme sampling...
15.
Verwoert G, Franco O, Hoeks A, Reneman R, Hofman A, V Duijn C, et al.
J Hypertens
. 2014 Jun;
32(8):1606-12.
PMID: 24886821
Objective: We studied whether arterial stiffness measured as aortic pulse wave velocity (aPWV) and carotid distensibility was associated with different subtypes of hypertension in a large population of untreated middle-aged...
16.
Leening M, Heeringa J, Deckers J, Franco O, Hofman A, Witteman J, et al.
Epidemiology
. 2014 Apr;
25(3):470-1.
PMID: 24713887
No abstract available.
17.
Leening M, Vedder M, Witteman J, Pencina M, Steyerberg E
Ann Intern Med
. 2014 Mar;
160(2):122-31.
PMID: 24592497
The net reclassification improvement (NRI) is an increasingly popular measure for evaluating improvements in risk predictions. This article details a review of 67 publications in high-impact general clinical journals that...
18.
Huang J, Huffman J, Yamakuchi M, Yamkauchi M, Trompet S, Asselbergs F, et al.
Arterioscler Thromb Vasc Biol
. 2014 Mar;
34(5):1093-101.
PMID: 24578379
Objective: Tissue plasminogen activator (tPA), a serine protease, catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for endogenous fibrinolysis. In some populations, elevated plasma levels of tPA...
19.
Wolbers M, Blanche P, Koller M, Witteman J, Gerds T
Biostatistics
. 2014 Feb;
15(3):526-39.
PMID: 24493091
The concordance probability is a widely used measure to assess discrimination of prognostic models with binary and survival endpoints. We formally define the concordance probability for a prognostic model of...
20.
Selwaness M, Van den Bouwhuijsen Q, Mattace-Raso F, Verwoert G, Hofman A, Franco O, et al.
Arterioscler Thromb Vasc Biol
. 2014 Feb;
34(4):927-32.
PMID: 24482373
Objective: The relation between arterial stiffness and atherosclerosis, and specifically the influence of arterial stiffness on plaque composition, is largely unknown. In a population-based study, we investigated the association between...