Jacqueline Bezencon
Overview
Explore the profile of Jacqueline Bezencon including associated specialties, affiliations and a list of published articles.
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10
Citations
172
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Recent Articles
1.
Bezencon J, Saran C, Hussner J, Beaudoin J, Zhang Y, Shen H, et al.
J Pharm Sci
. 2020 Oct;
110(1):404-411.
PMID: 33058892
Recent studies have focused on coproporphyrin (CP)-I and CP-III (CPs) as endogenous biomarkers for organic anion transporting polypeptides (OATPs). Previous data showed that CPs are also substrates of multidrug resistance-associated...
2.
Beaudoin J, Bezencon J, Sjostedt N, Fallon J, Brouwer K
Toxicol Sci
. 2020 Apr;
176(1):34-35.
PMID: 32294204
Organic solute transporter (OST) α/β is a key bile acid transporter expressed in various organs, including the liver under cholestatic conditions. However, little is known about the involvement of OSTα/β...
3.
Bezencon J, Beaudoin J, Ito K, Fu D, Roth S, Brock W, et al.
Drug Metab Dispos
. 2019 Jun;
47(8):899-906.
PMID: 31160314
Autosomal dominant polycystic kidney disease (ADPKD) is a common form of inherited polycystic kidney disease (PKD) and is a leading cause of kidney failure. Fluid-filled cysts develop in the kidneys...
4.
Beaudoin J, Bezencon J, Cao Y, Mizuno K, Roth S, Brock W, et al.
Drug Metab Dispos
. 2018 Dec;
47(2):155-163.
PMID: 30504136
Tolvaptan, a vasopressin V-receptor antagonist, has demonstrated efficacy in slowing kidney function decline in patients with autosomal dominant polycystic kidney disease (ADPKD). In the pivotal clinical trial, the incidence of...
5.
Malinen M, Ali I, Bezencon J, Beaudoin J, Brouwer K
Am J Physiol Gastrointest Liver Physiol
. 2018 Feb;
314(5):G597-G609.
PMID: 29420067
The heteromeric steroid transporter organic solute transporter α/β (OSTα/β, SLC51A/B) was discovered over a decade ago, but its physiological significance in the liver remains uncertain. A major challenge has been...
6.
Kleeb S, Jiang X, Frei P, Sigl A, Bezencon J, Bamberger K, et al.
J Med Chem
. 2016 Mar;
59(7):3163-82.
PMID: 26959338
The widespread occurrence of urinary tract infections has resulted in frequent antibiotic treatment, contributing to the emergence of antimicrobial resistance. Alternative approaches are therefore required. In the initial step of...
7.
Kiran Marelli U, Bezencon J, Puig E, Ernst B, Kessler H
Chemistry
. 2015 Apr;
21(22):8023-7.
PMID: 25917866
Recently, oral absorption of cyclic hexapeptides was improved by N-methylation of their backbone amides. However, the number and position of N-methylations or of solvent exposed NHs did not correlate to...
8.
Kleeb S, Pang L, Mayer K, Eris D, Sigl A, Preston R, et al.
J Med Chem
. 2015 Feb;
58(5):2221-39.
PMID: 25666045
Urinary tract infections (UTIs), predominantly caused by uropathogenic Escherichia coli (UPEC), belong to the most prevalent infectious diseases worldwide. The attachment of UPEC to host cells is mediated by FimH,...
9.
Bezencon J, Wittwer M, Cutting B, Smiesko M, Wagner B, Kansy M, et al.
J Pharm Biomed Anal
. 2014 Jan;
93:147-55.
PMID: 24462329
pKa values of acids and protonated bases have an essential impact on organic synthesis, medicinal chemistry, and material and food sciences. In drug discovery and development, they are of utmost...
10.
Klein T, Abgottspon D, Wittwer M, Rabbani S, Herold J, Jiang X, et al.
J Med Chem
. 2010 Nov;
53(24):8627-41.
PMID: 21105658
Urinary tract infection (UTI) by uropathogenic Escherichia coli (UPEC) is one of the most common infections, particularly affecting women. The interaction of FimH, a lectin located at the tip of...