Jacqueline A Koehler
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Explore the profile of Jacqueline A Koehler including associated specialties, affiliations and a list of published articles.
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19
Citations
572
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Recent Articles
1.
Hammoud R, Kaur K, Koehler J, Baggio L, Wong C, Advani K, et al.
JCI Insight
. 2024 Dec;
10(3).
PMID: 39723966
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are gut-derived peptide hormones that potentiate glucose-dependent insulin secretion. The clinical development of GIP receptor-GLP-1 receptor (GIPR-GLP-1R) multiagonists exemplified by tirzepatide...
2.
Forny Germano L, Koehler J, Baggio L, Cui F, Wong C, Rittig N, et al.
Mol Metab
. 2024 Aug;
89:102019.
PMID: 39216535
Objective: The development of glucagon-like peptide-1 receptor (GLP-1R) agonists for the treatment of type 2 diabetes and obesity has been accompanied by evidence for anti-inflammatory and cytoprotective actions in the...
3.
Wong C, McLean B, Baggio L, Koehler J, Hammoud R, Rittig N, et al.
Cell Metab
. 2023 Dec;
36(1):130-143.e5.
PMID: 38113888
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert anti-inflammatory effects relevant to the chronic complications of type 2 diabetes. Although GLP-1RAs attenuate T cell-mediated gut and systemic inflammation directly through the gut...
4.
Wong C, Yusta B, Koehler J, Baggio L, McLean B, Matthews D, et al.
Cell Metab
. 2022 Aug;
34(10):1514-1531.e7.
PMID: 36027914
Gut intraepithelial lymphocytes (IELs) are thought to calibrate glucagon-like peptide 1 (GLP-1) bioavailability, thereby regulating systemic glucose and lipid metabolism. Here, we show that the gut IEL GLP-1 receptor (GLP-1R)...
5.
Baggio L, Varin E, Koehler J, Cao X, Lokhnygina Y, Stevens S, et al.
Nat Commun
. 2020 Jul;
11(1):3766.
PMID: 32724076
Dipeptidyl peptidase-4 (DPP4) modulates inflammation by enzymatic cleavage of immunoregulatory peptides and through its soluble form (sDPP4) that directly engages immune cells. Here we examine whether reduction of DPP4 activity...
6.
Pujadas G, Varin E, Baggio L, Mulvihill E, Bang K, Koehler J, et al.
Mol Metab
. 2020 May;
39:101008.
PMID: 32389828
Objective: Glucose-dependent insulinotropic polypeptide (GIP) conveys information from ingested nutrients to peripheral tissues, signaling energy availability. The GIP Receptor (GIPR) is also expressed in the bone marrow, notably in cells...
7.
Panaro B, Yusta B, Matthews D, Koehler J, Song Y, Sandoval D, et al.
Mol Metab
. 2020 Apr;
37:100990.
PMID: 32278655
Objective: Glucagon-like peptide-1 is a nutrient-sensitive hormone secreted from enteroendocrine L cells within the small and large bowel. Although GLP-1 levels rise rapidly in response to food ingestion, the greatest...
8.
Song Y, Koehler J, Baggio L, Powers A, Sandoval D, Drucker D
Cell Metab
. 2019 Sep;
30(5):976-986.e3.
PMID: 31495689
The importance of pancreatic versus intestinal-derived GLP-1 for glucose homeostasis is controversial. We detected active GLP-1 in the mouse and human pancreas, albeit at extremely low levels relative to glucagon....
9.
Yusta B, Matthews D, Koehler J, Pujadas G, Kaur K, Drucker D
Endocrinology
. 2019 Jun;
160(8):1950-1963.
PMID: 31237617
Glucagon-like peptide-2 (GLP-2), secreted from enteroendocrine cells, attenuates gut motility, enhances barrier function, and augments nutrient absorption, actions mediated by a single GLP-2 receptor (GLP-2R). Despite extensive analyses, the precise...
10.
Varin E, Mulvihill E, Baggio L, Koehler J, Cao X, Seeley R, et al.
Cell Rep
. 2019 Jun;
27(11):3371-3384.e3.
PMID: 31189118
Glucagon-like peptide 1 (GLP-1) receptors are widely distributed throughout the nervous system, enabling physiological and pharmacological control of glucose and energy homeostasis. Here we elucidated the importance of Glp1r expression...