Jacob Piehler
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Explore the profile of Jacob Piehler including associated specialties, affiliations and a list of published articles.
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Articles
170
Citations
4606
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Recent Articles
1.
Broerman A, Pollmann C, Lichtenstein M, Jackson M, Tessmer M, Ryu W, et al.
bioRxiv
. 2024 Nov;
PMID: 39605600
Protein design has focused primarily on the design of ground states, ensuring they are sufficiently low energy to be highly populated. Designing the kinetics and dynamics of a system requires,...
2.
Ullrich T, Klimenkova O, Pollmann C, Lasram A, Hatskovska V, Maksymenko K, et al.
PLoS Biol
. 2024 Nov;
22(11):e3002883.
PMID: 39591631
Excessive cytokine signaling resulting from dysregulation of a cytokine or its receptor can be a main driver of cancer, autoimmune, or hematopoietic disorders. Here, we leverage protein design to create...
3.
Zoler E, Meyer T, Bellon J, Monnig M, Sun B, Piehler J, et al.
Sci Signal
. 2024 Nov;
17(863):eadl1892.
PMID: 39561221
Janus kinases (JAKs) bind to class I and II cytokine receptors, activating signaling and regulating gene transcription through signal transducer and activator of transcription (STAT) proteins. Type I interferons (IFNs)...
4.
Winkelmann H, Richter C, Eising J, Piehler J, Kurre R
Nat Commun
. 2024 Jul;
15(1):5813.
PMID: 38987559
Total internal reflection fluorescence (TIRF) microscopy offers powerful means to uncover the functional organization of proteins in the plasma membrane with very high spatial and temporal resolution. Traditional TIRF illumination,...
5.
Caveney N, Rodriguez G, Pollmann C, Meyer T, Borowska M, Wilson S, et al.
Mol Cell
. 2024 Apr;
84(10):1995-2005.e7.
PMID: 38614096
Cytokines regulate immune responses by binding to cell surface receptors, including the common subunit beta (βc), which mediates signaling for GM-CSF, IL-3, and IL-5. Despite known roles in inflammation, the...
6.
Gardner S, Jin Y, Fyfe P, Voisin T, Bellon J, Pohler E, et al.
Nat Commun
. 2024 Mar;
15(1):2071.
PMID: 38453915
IL-11 and IL-6 activate signalling via assembly of the cell surface receptor gp130; however, it is unclear how signals are transmitted across the membrane to instruct cellular responses. Here we...
7.
Bekku Y, Zotter B, You C, Piehler J, Leonard W, Salzer J
Dev Cell
. 2024 Feb;
59(5):627-644.e10.
PMID: 38309265
Axons undergo striking changes in their content and distribution of cell adhesion molecules (CAMs) and ion channels during myelination that underlies the switch from continuous to saltatory conduction. These changes...
8.
Tsutsumi N, Masoumi Z, James S, Tucker J, Winkelmann H, Grey W, et al.
Cell
. 2023 Aug;
186(19):4189-4203.e22.
PMID: 37633268
Thrombopoietin (THPO or TPO) is an essential cytokine for hematopoietic stem cell (HSC) maintenance and megakaryocyte differentiation. Here, we report the 3.4 Å resolution cryoelectron microscopy structure of the extracellular...
9.
Nair P, Piehler J, Tvorogov D, Ross D, Lopez A, Gotlib J, et al.
Blood Cancer Discov
. 2023 Jul;
4(5):352-364.
PMID: 37498362
Significance: The JAK inhibitors currently used for the treatment of MPNs are effective for symptom management but not for disease eradication, primarily because they are not strongly selective for the...
10.
Tsirigotaki A, Dansercoer A, Verschueren K, Markovic I, Pollmann C, Hafer M, et al.
Nat Struct Mol Biol
. 2023 Mar;
30(4):551-563.
PMID: 36959263
The adipokine Leptin activates its receptor LEP-R in the hypothalamus to regulate body weight and exerts additional pleiotropic functions in immunity, fertility and cancer. However, the structure and mechanism of...