Jacob Jelsing
Overview
Explore the profile of Jacob Jelsing including associated specialties, affiliations and a list of published articles.
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89
Citations
2488
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Recent Articles
1.
Nielsen M, Gillum M, Vrang N, Jelsing J, Hansen H, Feigh M, et al.
Am J Physiol Gastrointest Liver Physiol
. 2023 Feb;
324(5):G378-G388.
PMID: 36852934
Fibroblast growth factor 21 (FGF21) plays a key role in hepatic lipid metabolism and long-acting FGF21 analogs have emerged as promising drug candidates for the treatment of nonalcoholic steatohepatitis (NASH)....
2.
Hagemann C, Legart C, Mollerhoj M, Madsen M, Hansen H, Konig M, et al.
PLoS One
. 2022 Oct;
17(10):e0275901.
PMID: 36260611
Non-invasive biomarkers of non-alcoholic fatty liver disease (NAFLD) supporting diagnosis and monitoring disease progression are urgently needed. The present study aimed to establish a bioinformatics pipeline capable of defining and...
3.
Ostergaard M, Sembach F, Skytte J, Roostalu U, Secher T, Overgaard A, et al.
Kidney360
. 2022 Apr;
1(6):469-479.
PMID: 35368599
Background: Glomerular hypertrophy is a hallmark of kidney injury in metabolically induced renal diseases such as obesity-associated glomerulopathies and diabetic nephropathy (DN). Methods: Using light sheet fluorescent microscopy (LSFM) and...
4.
Mollerhoj M, Veidal S, Thrane K, Oro D, Overgaard A, Salinas C, et al.
Clin Transl Sci
. 2022 Feb;
15(5):1167-1186.
PMID: 35143711
Non-alcoholic steatohepatitis (NASH) has emerged as a major challenge for public health because of high global prevalence and lack of evidence-based therapies. Most animal models of NASH lack sufficient validation...
5.
Alexopoulou F, Bech E, Pedersen S, Thorbek D, Leurs U, Rudkjaer L, et al.
Sci Rep
. 2022 Feb;
12(1):1696.
PMID: 35105898
Prolactin-releasing peptide (PrRP) is an endogenous neuropeptide involved in appetite regulation and energy homeostasis. PrRP binds with high affinity to G-protein coupled receptor 10 (GPR10) and with lesser activity towards...
6.
Sembach F, Agidius H, Fink L, Secher T, Aarup A, Jelsing J, et al.
Dis Model Mech
. 2021 Sep;
14(10).
PMID: 34494644
The current understanding of molecular mechanisms driving diabetic kidney disease (DKD) is limited, partly due to the complex structure of the kidney. To identify genes and signalling pathways involved in...
7.
Ostergaard M, Secher T, Christensen M, Salinas C, Roostalu U, Skytte J, et al.
Am J Physiol Renal Physiol
. 2021 Jun;
321(2):F149-F161.
PMID: 34180715
Hypertension is a critical comorbidity for progression of diabetic kidney disease (DKD). To facilitate the development of novel therapeutic interventions with the potential to control disease progression, there is a...
8.
Skovbjerg G, Roostalu U, Hansen H, Lutz T, Le Foll C, Salinas C, et al.
Eur J Neurosci
. 2021 Apr;
PMID: 33905587
The pancreatic hormone amylin plays a central role in regulating energy homeostasis and glycaemic control by stimulating satiation and reducing food reward, making amylin receptor agonists attractive for the treatment...
9.
Hansen H, Gronlund R, Baader-Pagler T, Haebel P, Tammen H, Larsen L, et al.
Sci Rep
. 2021 Apr;
11(1):8060.
PMID: 33850212
Dipeptidyl peptidase IV (DPP-IV) inhibitors improve glycemic control by prolonging the action of glucagon-like peptide-1 (GLP-1). In contrast to GLP-1 analogues, DPP-IV inhibitors are weight-neutral. DPP-IV cleavage of PYY and...
10.
Roostalu U, Thisted L, Skytte J, Salinas C, Pedersen P, Hecksher-Sorensen J, et al.
Sci Rep
. 2021 Mar;
11(1):5241.
PMID: 33664407
Angiotensin converting enzyme inhibitors, among them captopril, improve survival following myocardial infarction (MI). The mechanisms of captopril action remain inadequately understood due to its diverse effects on multiple signalling pathways...