Jacob J Kennedy
Overview
Explore the profile of Jacob J Kennedy including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
1021
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Recent Articles
1.
Naru J, Othus M, Lin C, Biernacki M, Bleakley M, Chauncey T, et al.
EJHaem
. 2024 Dec;
5(6):1243-1251.
PMID: 39691254
Introduction: Acute myeloid leukemia (AML) remains one of the deadliest hematopoietic malignancies. A better understanding of the molecular biology governing AML may lead to improved risk stratification and facilitate the...
2.
Zheng X, Sarkar A, Lotana H, Syed A, Nguyen H, Ivey R, et al.
Nature
. 2024 Sep;
633(8031):932-940.
PMID: 39232161
CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression. Here we demonstrate that CDK5 is active during mitosis and is...
3.
Whiteaker J, Zhao L, Kennedy J, Ivey R, Paulovich A
Methods Mol Biol
. 2024 Jul;
2823:253-267.
PMID: 39052225
Targeted proteomics enables sensitive and specific quantification of proteins and post-translational modifications. By coupling peptide immunoaffinity enrichment with targeted mass spectrometry, we have developed the methodology for multiplexed quantification of...
4.
Whiteaker J, Zhao L, Schoenherr R, Huang D, Kennedy J, Ivey R, et al.
Sci Data
. 2024 Jun;
11(1):682.
PMID: 38918394
Immunotherapies are revolutionizing cancer care, but many patients do not achieve durable responses and immune-related adverse events are difficult to predict. Quantifying the hundreds of proteins involved in cancer immunity...
5.
Chowdhury S, Kennedy J, Ivey R, Murillo O, Hosseini N, Song X, et al.
Cell
. 2024 Feb;
187(4):1016.
PMID: 38364782
No abstract available.
6.
Petralia F, Ma W, Yaron T, Caruso F, Tignor N, Wang J, et al.
Cell
. 2024 Feb;
187(5):1255-1277.e27.
PMID: 38359819
Despite the successes of immunotherapy in cancer treatment over recent decades, less than <10%-20% cancer cases have demonstrated durable responses from immune checkpoint blockade. To enhance the efficacy of immunotherapies,...
7.
Lin C, Schoenherr R, Voytovich U, Ivey R, Kennedy J, Whiteaker J, et al.
Sci Data
. 2024 Jan;
11(1):27.
PMID: 38177134
A wealth of proteogenomic data has been generated using cancer samples to deepen our understanding of the mechanisms of cancer and how biological networks are altered in association with somatic...
8.
Phipps W, Kilgore M, Kennedy J, Whiteaker J, Hoofnagle A, Paulovich A
Mol Cell Proteomics
. 2023 Sep;
22(11):100648.
PMID: 37730181
The evaluation of biopsied solid organ tissue has long relied on visual examination using a microscope. Immunohistochemistry is critical in this process, labeling and detecting cell lineage markers and therapeutic...
9.
Chowdhury S, Kennedy J, Ivey R, Murillo O, Hosseini N, Song X, et al.
Cell
. 2023 Aug;
186(16):3476-3498.e35.
PMID: 37541199
To improve the understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two validation cohorts across...
10.
Lundeen R, Kennedy J, Murillo O, Ivey R, Zhao L, Schoenherr R, et al.
Mol Cell Proteomics
. 2023 Jul;
22(9):100621.
PMID: 37478973
Targeted mass spectrometry (MS)-based proteomic assays, such as multiplexed multiple reaction monitoring (MRM)-MS assays, enable sensitive and specific quantification of proteotypic peptides as stoichiometric surrogates for proteins. Efforts are underway...