Jacob G Jansen
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Explore the profile of Jacob G Jansen including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
669
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0
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Recent Articles
1.
Ijsselsteijn R, van Hees S, Drost M, Jansen J, de Wind N
Carcinogenesis
. 2021 Dec;
43(2):160-169.
PMID: 34919656
The prevalent cancer predisposition Lynch syndrome (LS, OMIM #120435) is caused by an inherited heterozygous defect in any of the four core DNA mismatch repair (MMR) genes MSH2, MSH6, MLH1...
2.
Ijsselsteijn R, Jansen J, de Wind N
DNA Repair (Amst)
. 2020 Oct;
93:102923.
PMID: 33087264
Canonical DNA mismatch repair (MMR) excises base-base mismatches to increase the fidelity of DNA replication. Thus, loss of MMR leads to increased spontaneous mutagenesis. MMR genes also are involved in...
3.
4.
Jansen J, Tsaalbi-Shtylik A, de Wind N
Oncotarget
. 2015 Aug;
6(23):19342-3.
PMID: 26305846
No abstract available.
5.
FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress
Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y, et al.
Nucleic Acids Res
. 2015 Jul;
43(17):8325-39.
PMID: 26187992
REV1 is a eukaryotic member of the Y-family of DNA polymerases involved in translesion DNA synthesis and genome mutagenesis. Recently, REV1 is also found to function in homologous recombination. However,...
6.
Tsaalbi-Shtylik A, Jansen J, de Wind N
Cell Cycle
. 2015 Jun;
14(15):2377-8.
PMID: 26102362
No abstract available.
7.
Tomas-Roca L, Tsaalbi-Shtylik A, Jansen J, Singh M, Epstein J, Altunoglu U, et al.
Nat Commun
. 2015 Jun;
6:7199.
PMID: 26068067
Möbius syndrome (MBS) is a neurological disorder that is characterized by paralysis of the facial nerves and variable other congenital anomalies. The aetiology of this syndrome has been enigmatic since...
8.
Tsaalbi-Shtylik A, Ferras C, Pauw B, Hendriks G, Temviriyanukul P, Carlee L, et al.
J Cell Biol
. 2015 Apr;
209(1):33-46.
PMID: 25869665
In addition to correcting mispaired nucleotides, DNA mismatch repair (MMR) proteins have been implicated in mutagenic, cell cycle, and apoptotic responses to agents that induce structurally aberrant nucleotide lesions. Here,...
9.
Jansen J, Tsaalbi-Shtylik A, de Wind N
DNA Repair (Amst)
. 2015 Feb;
29:56-64.
PMID: 25655219
Most spontaneous and DNA damage-induced nucleotide substitutions in eukaryotes depend on translesion synthesis polymerases Rev1 and Pol ζ, the latter consisting of the catalytic subunit Rev3 and the accessory protein...
10.
Wit N, Buoninfante O, van den Berk P, Jansen J, Hogenbirk M, de Wind N, et al.
Nucleic Acids Res
. 2014 Dec;
43(1):282-94.
PMID: 25505145
Translesion synthesis (TLS) provides a highly conserved mechanism that enables DNA synthesis on a damaged template. TLS is performed by specialized DNA polymerases of which polymerase (Pol) κ is important...