Jacob Favret
Overview
Explore the profile of Jacob Favret including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
150
Followers
0
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Recent Articles
1.
Favret J, Maulik M, Masoom R, Kushwaha M, Thompson D, Browne R, et al.
Sci Rep
. 2024 Dec;
14(1):31822.
PMID: 39738378
Lipocalin-2 (LCN2) is an acute-phase secretory molecule significantly upregulated in various neuroinflammatory and demyelinating conditions. Krabbe disease (KD) is a neurodegenerative lysosomal disorder caused by a galactosylceramidase (GALC) deficiency, accumulating...
2.
Favret J, Nawaz M, Patel M, Khaledi H, Gelb M, Shin D
Mol Ther
. 2024 May;
32(7):2207-2222.
PMID: 38734898
Lysosomal galactosylceramidase (GALC) is expressed in all brain cells, including oligodendrocytes (OLs), microglia, and astrocytes, although the cell-specific function of GALC is largely unknown. Mutations in GALC cause Krabbe disease...
3.
Scarneo S, Smith A, Favret J, OConnell R, Pickeral J, Yang K, et al.
Sci Rep
. 2022 Oct;
12(1):18091.
PMID: 36302951
Heat shock protein 90 (Hsp90) maintains cellular proteostasis during stress and has been under investigation as a therapeutic target in cancer for over two decades. We and others have identified...
4.
Kreher C, Favret J, Weinstock N, Maulik M, Hong X, Gelb M, et al.
PLoS Biol
. 2022 Jul;
20(7):e3001661.
PMID: 35789331
Krabbe disease is caused by a deficiency of the lysosomal galactosylceramidase (GALC) enzyme, which results in the accumulation of galactosylceramide (GalCer) and psychosine. In Krabbe disease, the brunt of demyelination...
5.
Feltri M, Weinstock N, Favret J, Dhimal N, Wrabetz L, Shin D
Glia
. 2021 Apr;
69(10):2309-2331.
PMID: 33851745
Globoid cell leukodystrophy (GLD), also known as Krabbe disease, is a lysosomal storage disorder causing extensive demyelination in the central and peripheral nervous systems. GLD is caused by loss-of-function mutations...
6.
Kreher C, Favret J, Maulik M, Shin D
Biomolecules
. 2021 Apr;
11(3).
PMID: 33803137
Lysosomes are cellular organelles that contain various acidic digestive enzymes. Despite their small size, they have multiple functions. Lysosomes remove or recycle unnecessary cell parts. They repair damaged cellular membranes...
7.
Weinstock N, Kreher C, Favret J, Nguyen D, Bongarzone E, Wrabetz L, et al.
Nat Commun
. 2020 Oct;
11(1):5356.
PMID: 33097716
Krabbe disease (KD) is caused by a deficiency of galactosylceramidase (GALC), which induces demyelination and neurodegeneration due to accumulation of cytotoxic psychosine. Hematopoietic stem cell transplantation (HSCT) improves clinical outcomes...
8.
Kwilasz A, Green Fulgham S, Ellis A, Patel H, Duran-Malle J, Favret J, et al.
Brain Behav Immun
. 2018 Nov;
76:116-125.
PMID: 30453021
Neuropathic pain is a widespread problem which remains poorly managed by currently available therapeutics. Peripheral nerve injury and inflammation leads to changes at the nerve injury site, including activation of...
9.
Kwilasz A, Ellis A, Wieseler J, Loram L, Favret J, McFadden A, et al.
Brain Behav Immun
. 2018 Jan;
69:470-479.
PMID: 29366930
Central neuropathic pain is a debilitating outcome of spinal cord injury (SCI) and current treatments to alleviate this pain condition are ineffective. A growing body of literature suggests that activating...
10.
Ellis A, Grace P, Wieseler J, Favret J, Springer K, Skarda B, et al.
Brain Behav Immun
. 2016 Aug;
58:348-356.
PMID: 27519154
Central neuropathic pain (CNP) is a pervasive, debilitating problem that impacts thousands of people living with central nervous system disorders, including spinal cord injury (SCI). Current therapies for treating this...