Jack J W A van Loon
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Explore the profile of Jack J W A van Loon including associated specialties, affiliations and a list of published articles.
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66
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1094
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Recent Articles
11.
Isasi E, Isasi M, van Loon J
Front Physiol
. 2022 Sep;
13:952723.
PMID: 36105282
Gravity plays a crucial role in physiology. The lack of gravity, like in long duration spaceflight missions, cause pathologies in , the musculoskeletal system, cardiovascular deconditioning, immune system deprivation or...
12.
Jansen I, van Velzen T, de Vries T, Szulcek R, van Loon J
Front Cell Dev Biol
. 2022 Sep;
10:921066.
PMID: 36060806
In several diseases, bone resorption by osteoclasts is dysregulated. Thus far, no simple technique for real-time measurement of resorption is available. Here, we introduce an impedimetric bioassay for real-time monitoring...
13.
Simon A, Tozar T, Smarandache A, Boni M, Stoicu A, Dowson A, et al.
Molecules
. 2022 Mar;
27(5).
PMID: 35268828
Pharmaceuticals carried into space are subjected to different gravitational conditions. Hypergravity is encountered in the first stage, during spacecraft launching. The stability of medicines represents a critical element of space...
14.
Aronne G, Muthert L, Izzo L, Romano L, Iovane M, Capozzi F, et al.
Life Sci Space Res (Amst)
. 2022 Jan;
32:8-16.
PMID: 35065766
Long-duration space missions will need to rely on the use of plants in bio-regenerative life support systems (BLSSs) because these systems can produce fresh food and oxygen, reduce carbon dioxide...
15.
Herranz R, Valbuena M, Manzano A, Kamal K, Villacampa A, Ciska M, et al.
Methods Mol Biol
. 2021 Oct;
2368:241-265.
PMID: 34647260
Simulated microgravity and partial gravity research on Earth is a necessary complement to space research in real microgravity due to limitations of access to spaceflight. However, the use of ground-based...
16.
Salvetti A, DeglInnocenti A, Gambino G, van Loon J, Ippolito C, Ghelardoni S, et al.
J Biomed Mater Res A
. 2021 May;
109(11):2322-2333.
PMID: 33960131
Gravity alterations elicit complex and mostly detrimental effects on biological systems. Among these, a prominent role is occupied by oxidative stress, with consequences for tissue homeostasis and development. Studies in...
17.
Azevedo C, Macedo M, Almeida A, Pinto S, van Loon J, Sarmento B
Eur J Pharm Biopharm
. 2021 Mar;
163:38-48.
PMID: 33785416
The oral administration of drugs remains a challenge due to rapid enzymatic degradation and minimal absorption in the gastrointestinal tract. Mechanical forces, namely hypergravity, can interfere with cellular integrity and...
18.
Eckert J, van Loon J, Eng L, Schmidt T
Biophys J
. 2021 Mar;
120(5):773-780.
PMID: 33657362
Cells sense and react on changes of the mechanical properties of their environment and, likewise, respond to external mechanical stress applied to them. However, whether the gravitational field as overall...
19.
de Sousa N, Caporicci M, Vandersteen J, Rojo-Laguna J, Salo E, Adell T, et al.
NPJ Microgravity
. 2020 Sep;
6:25.
PMID: 32964111
Although many examples of simulated and real microgravity demonstrating their profound effect on biological systems are described in literature, few reports deal with hypergravity and vibration effects, the levels of...
20.
Eekhoff E, Micha D, Forouzanfar T, de Vries T, Netelenbos J, Klein-Nulend J, et al.
Front Endocrinol (Lausanne)
. 2020 Aug;
11:481.
PMID: 32849274
In the field of rare bone diseases in particular, a broad care team of specialists embedded in multidisciplinary clinical and research environment is essential to generate new therapeutic solutions and...