Jack A Dempsey
Overview
Explore the profile of Jack A Dempsey including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
300
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Szymczak S, Szpurka A, Lu Z, Dempsey J
Thyroid
. 2023 Jun;
33(12):1493-1495.
PMID: 37376747
No abstract available.
2.
Blosser W, Dempsey J, McNulty A, Rao X, Ebert P, Lowery C, et al.
Oncotarget
. 2020 Feb;
11(3):216-236.
PMID: 32076484
The combined influence of oncogenic drivers, genomic instability, and/or DNA damage repair deficiencies increases replication stress in cancer. Cells with high replication stress rely on the upregulation of checkpoints like...
3.
Du J, Yan L, Torres R, Gong X, Bian H, Marugan C, et al.
Mol Cancer Ther
. 2019 Sep;
18(12):2207-2219.
PMID: 31530649
Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression. Aurora A depletion primarily leads to mitotic spindle...
4.
Schaer D, Beckmann R, Dempsey J, Huber L, Forest A, Amaladas N, et al.
Cell Rep
. 2018 Mar;
22(11):2978-2994.
PMID: 29539425
Abemaciclib, an inhibitor of cyclin dependent kinases 4 and 6 (CDK4/6), has recently been approved for the treatment of hormone receptor-positive breast cancer. In this study, we use murine syngeneic...
5.
Zhu G, Conner S, Zhou X, Chan H, Shih C, Engler T, et al.
Bioorg Med Chem Lett
. 2004 May;
14(12):3057-61.
PMID: 15149644
The synthesis of a novel series of 1,7-annulated indolocarbazoles 2 and 16 is described. These compounds were found to be potent cyclin dependent kinase inhibitors with good antiproliferative activity against...
6.
Sanchez-Martinez C, Shih C, Zhu G, Li T, Brooks H, Patel B, et al.
Bioorg Med Chem Lett
. 2003 Oct;
13(21):3841-6.
PMID: 14552792
A series of indolo[2,3-a]pyrrolo[3,4-c]carbazoles and their bis-indolylmaleimides precursors have been prepared in order to compare their activity as D1-CDK4 inhibitors. Both enzymatic and antiproliferative assays have shown that the structurally...
7.
Sanchez-Martinez C, Shih C, Faul M, Zhu G, Paal M, Somoza C, et al.
Bioorg Med Chem Lett
. 2003 Oct;
13(21):3835-9.
PMID: 14552791
The synthesis of new analogues of Arcyriaflavin A in which one indole ring is replaced by an aryl or heteroaryl ring is described. These new series of aryl[a]pyrrolo[3,4-c]carbazoles were evaluated...
8.
Engler T, Furness K, Malhotra S, Sanchez-Martinez C, Shih C, Xie W, et al.
Bioorg Med Chem Lett
. 2003 Jun;
13(14):2261-7.
PMID: 12824014
The synthesis and CDK inhibitory properties of a series of indolo[6,7-a]pyrrolo[3,4-c]carbazoles is reported. In addition to their potent CDK activity, the compounds display antiproliferative activity against two human cancer cell...
9.
Zhu G, Conner S, Zhou X, Shih C, Li T, Anderson B, et al.
J Med Chem
. 2003 May;
46(11):2027-30.
PMID: 12747775
Novel substituted indolocarbazoles were synthesized, and their kinase inhibitory capability was evaluated in vitro. 6-Substituted indolocarbazoles 4 were found to be potent and selective D1/CDK4 inhibitors. 4d and 4h exhibited...
10.
Zhu G, Conner S, Zhou X, Shih C, Brooks H, Considine E, et al.
Bioorg Med Chem Lett
. 2003 Mar;
13(7):1231-5.
PMID: 12657252
A novel series of pyrrolo[3,4-c] carbazoles fused with a quinolinyl/isoquinolinyl moiety were synthesized and their D1/CDK4 inhibitory and antiproliferative activity were evaluated. Compound 8H, 14H-isoquinolinyl[6,5-a]-pyrrolo[3,4-c]carbazole-7,9-dione (1d) was found to be...