Jack A Bryant
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Explore the profile of Jack A Bryant including associated specialties, affiliations and a list of published articles.
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24
Citations
435
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Recent Articles
1.
Gray J, Torres V, Goodall E, McKeand S, Scales D, Collins C, et al.
Elife
. 2024 Aug;
12.
PMID: 39189918
is a global public health concern due to the rising myriad of hypervirulent and multidrug-resistant clones both alarmingly associated with high mortality. The molecular mechanisms underpinning these recalcitrant infection, and...
2.
Wotherspoon P, Johnston H, Hardy D, Holyfield R, Bui S, Ratkeviciute G, et al.
Nat Commun
. 2024 Jul;
15(1):6394.
PMID: 39080293
The Maintenance of Lipid Asymmetry (Mla) pathway is a multicomponent system found in all gram-negative bacteria that contributes to virulence, vesicle blebbing and preservation of the outer membrane barrier function....
3.
Alodaini D, Hernandez-Rocamora V, Boelter G, Ma X, Alao M, Doherty H, et al.
mBio
. 2024 Mar;
15(4):e0032524.
PMID: 38426748
Gram-negative bacteria have a thin peptidoglycan layer between the cytoplasmic and outer membranes protecting the cell from osmotic challenges. Hydrolases of this structure are needed to cleave bonds to allow...
4.
Goodall E, Morris F, McKeand S, Sullivan R, Warner I, Sheehan E, et al.
Microbiol Spectr
. 2022 Jul;
10(4):e0083322.
PMID: 35856675
In recent years the availability of genome sequence information has grown logarithmically resulting in the identification of a plethora of uncharacterized genes. To address this gap in functional annotation, many...
5.
Boelter G, Bryant J, Doherty H, Wotherspoon P, Alodaini D, Ma X, et al.
Microbiology (Reading)
. 2022 May;
168(5).
PMID: 35604759
Bacterial amidases are essential to split the shared envelope of adjunct daughter cells to allow cell separation. Their activity needs to be precisely controlled to prevent cell lysis. In amidase...
6.
Bryant J, Riordan L, Watson R, Nikoi N, Trzaska W, Slope L, et al.
Glob Chall
. 2022 May;
6(5):2100138.
PMID: 35602408
There is an increasing focus in healthcare environments on combatting antimicrobial resistant infections. While bacterial infections are well reported, infections caused by fungi receive less attention, yet have a broad...
7.
Watson R, Oldfield M, Bryant J, Riordan L, Hill H, Watts J, et al.
Sci Rep
. 2022 Mar;
12(1):2803.
PMID: 35264599
The COVID-19 pandemic has demonstrated the real need for mechanisms to control the spread of airborne respiratory pathogens. Thus, preventing the spread of disease from pathogens has come to the...
8.
Freire C, Silva R, Ruiz R, Pimenta D, Bryant J, Henderson I, et al.
Front Immunol
. 2022 Mar;
13:844878.
PMID: 35251044
Several strategies are used by to evade the host innate immune system in the blood, such as the cleavage of complement system proteins by secreted proteases. Members of the Serine...
9.
Goodall E, Isom G, Rooke J, Pullela K, Icke C, Yang Z, et al.
PLoS Genet
. 2021 Dec;
17(12):e1009586.
PMID: 34941903
The cell envelope is essential for viability in all domains of life. It retains enzymes and substrates within a confined space while providing a protective barrier to the external environment....
10.
Nikoi N, Berwick M, Bryant J, Riordan L, Slope L, Peacock A, et al.
Curr Eye Res
. 2021 Apr;
46(5):751-757.
PMID: 33896277
Aim: The development of a polyarginine cell-penetrating peptide (CPP) could enable the treatment of age-related macular degeneration, with drugs like bevacizumab, to be administered using eye drops instead of intravitreal...