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Jacintha OSullivan

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Articles 113
Citations 2209
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Recent Articles
1.
OConnell F, Mylod E, Donlon N, Davern M, Butler C, OConnor N, et al.
Transl Oncol . 2025 Feb; 53:102302. PMID: 39965288
Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited responses to standard of care treatments including chemotherapy and chemoradiotherapy. OAC has one of the strongest associations with obesity, its...
2.
Kane L, Flood B, Manils J, McSkeane D, Smith A, Tosetto M, et al.
Gastro Hep Adv . 2025 Jan; 4(2):100552. PMID: 39866724
Background And Aims: Colorectal cancer (CRC) is the second most deadly cancer globally. The rapidly rising incidence rate of CRC, coupled with increased diagnoses in individuals <50 years, indicates that...
3.
Murchu M, Lin X, Tutty M, Cahill C, Miller I, Jensen L, et al.
Cancer Lett . 2024 Dec; 611():217406. PMID: 39716484
Radiotherapy is used to treat over 50 % of cancer patients. It is often used in combination with surgery, chemotherapy, and immunotherapy, for cancers of the breast, lung, oesophagus, and...
4.
Marcone S, Spadavecchia J, Khan M, Vella G, OConnell F, Pendino M, et al.
Cancers (Basel) . 2024 Dec; 16(23). PMID: 39682192
Methods: To overcome these limitations, pyrazinib was conjugated with gold nanoparticles (AuNP-P3), creating a novel formulation designed to enhance solubility, maintain bioactivity, and enable targeted delivery to tumour sites. Results:...
5.
OBrien R, Meltzer S, Buckley C, Heeran A, Nugent T, Donlon N, et al.
Cancer Lett . 2024 Sep; 604:217253. PMID: 39278399
Resistance to neoadjuvant chemoradiation therapy (neo-CRT) is a significant clinical problem in the treatment of locally advanced rectal cancer. Identification of novel therapeutic targets and biomarkers predicting therapeutic response is...
6.
Sharma S, Carey N, McConnell D, Lowery M, OSullivan J, McCullagh L
Pharmacoeconomics . 2024 Jul; 42(10):1091-1110. PMID: 39060831
Background: Recent advances in the development of biomarker-directed therapy and immunotherapy, for advanced and metastatic gastric cancers, have the potential to improve survival and quality of life. Much attention has...
7.
OSullivan N, Temperley H, Kyle E, Sweeney K, ONeill M, Gilham C, et al.
Int J Colorectal Dis . 2024 May; 39(1):82. PMID: 38809315
Introduction: Circulating tumour DNA (ctDNA) has emerged as a promising biomarker in various cancer types, including locally advanced rectal cancer (LARC), offering potential insights into disease progression, treatment response and...
8.
Temperley H, Fannon T, OSullivan N, ONeill M, Mac Curtain B, Gilham C, et al.
Int J Mol Sci . 2024 Apr; 25(7). PMID: 38612815
This systematic review investigates the potential of circulating tumour DNA (ctDNA) as a predictive biomarker in the management and prognosis of squamous cell carcinoma of the anal canal (SCCA). PubMed,...
9.
Murphy D, Walsh A, Stein L, Petrasca A, Cox D, Brown K, et al.
Int J Mol Sci . 2024 Mar; 25(5). PMID: 38474145
Neutrophils are dynamic cells, playing a critical role in pathogen clearance; however, neutrophil infiltration into the tissue can act as a double-edged sword. They are one of the primary sources...
10.
Mitchelson K, OConnell F, OSullivan J, Roche H
Metabolites . 2024 Jan; 14(1). PMID: 38248845
Obesity is a major driving factor in the incidence, progression, and poor treatment response in gastrointestinal cancers. Herein, we conducted a comprehensive analysis of the impact of obesity and its...