Jacek W Sikora
Overview
Explore the profile of Jacek W Sikora including associated specialties, affiliations and a list of published articles.
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7
Citations
230
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Recent Articles
1.
Melani R, Gerbasi V, Anderson L, Sikora J, Toby T, Hutton J, et al.
Science
. 2022 Jan;
375(6579):411-418.
PMID: 35084980
Human biology is tightly linked to proteins, yet most measurements do not precisely determine alternatively spliced sequences or posttranslational modifications. Here, we present the primary structures of ~30,000 unique proteoforms,...
2.
Abshiru N, Sikora J, Camarillo J, Morris J, Compton P, Lee T, et al.
PLoS One
. 2020 Oct;
15(10):e0240829.
PMID: 33104722
Histone post-translational modifications (PTMs) create a powerful regulatory mechanism for maintaining chromosomal integrity in cells. Histone acetylation and methylation, the most widely studied histone PTMs, act in concert with chromatin-associated...
3.
Ling T, Birger Y, Stankiewicz M, Ben-Haim N, Kalisky T, Rein A, et al.
Blood
. 2019 Aug;
134(19):1619-1631.
PMID: 31409672
Mutations in GATA1, which lead to expression of the GATA1s isoform that lacks the GATA1 N terminus, are seen in patients with Diamond-Blackfan anemia (DBA). In our efforts to better...
4.
Camarillo J, Swaminathan S, Abshiru N, Sikora J, Thomas P, Kelleher N
J Am Soc Mass Spectrom
. 2019 Jul;
30(12):2526-2534.
PMID: 31286445
Histone posttranslational modifications (PTMs) are essential for regulating chromatin and maintaining gene expression throughout cell differentiation. Despite the deep level of understanding of immunophenotypic differentiation pathways in hematopoietic cells, few...
5.
Killinger B, Madaj Z, Sikora J, Rey N, Haas A, Vepa Y, et al.
Sci Transl Med
. 2018 Nov;
10(465).
PMID: 30381408
The pathogenesis of Parkinson's disease (PD) involves the accumulation of aggregated α-synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we determined the capacity of the appendix...
6.
Gruppuso P, Boylan J, Zabala V, Neretti N, Abshiru N, Sikora J, et al.
PLoS One
. 2018 Sep;
13(9):e0203351.
PMID: 30192817
Chromatin structure, a key contributor to the regulation of gene expression, is modulated by a broad array of histone post-translational modifications (PTMs). Taken together, these "histone marks" comprise what is...
7.
Riley N, Sikora J, Seckler H, Greer J, Fellers R, LeDuc R, et al.
Anal Chem
. 2018 Jun;
90(14):8553-8560.
PMID: 29924586
High-throughput top-down proteomic experiments directly identify proteoforms in complex mixtures, making high quality tandem mass spectra necessary to deeply characterize proteins with many sources of variation. Collision-based dissociation methods offer...