Jaby Jacob
Overview
Explore the profile of Jaby Jacob including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
718
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Recent Articles
1.
Latypov R, Liu D, Jacob J, Harvey T, Bondarenko P, Kleemann G, et al.
Biochemistry
. 2009 Oct;
48(46):10934-47.
PMID: 19839644
Conformational properties of the folded and unfolded ensembles of human interleukin-1 receptor antagonist (IL-1ra) are strongly denaturant-dependent as evidenced by high-resolution two-dimensional nuclear magnetic resonance (NMR), limited proteolysis, and small-angle...
2.
Van Buren N, Rehder D, Gadgil H, Matsumura M, Jacob J
J Pharm Sci
. 2008 Aug;
98(9):3013-30.
PMID: 18680168
Two major aggregation pathways observed in an IgG2 molecule are described. Different aggregate species generated by long-term incubation of the antibody at 37 degrees C were collected by a semi-preparative...
3.
McAuley A, Jacob J, Kolvenbach C, Westland K, Lee H, Brych S, et al.
Protein Sci
. 2007 Dec;
17(1):95-106.
PMID: 18156469
Recombinant human monoclonal antibodies have become important protein-based therapeutics for the treatment of various diseases. The antibody structure is complex, consisting of beta-sheet rich domains stabilized by multiple disulfide bridges....
4.
Xiao G, Bondarenko P, Jacob J, Chu G, Chelius D
Anal Chem
. 2007 Feb;
79(7):2714-21.
PMID: 17313184
We have developed a new method for identification and quantification of succinimide in proteins. The method utilizes 18O water to monitor succinimide hydrolysis. 18O-labeled isoaspartic acid and aspartic acid peptides...
5.
Jacob J, Dothager R, Thiyagarajan P, Sosnick T
J Mol Biol
. 2007 Feb;
367(3):609-15.
PMID: 17292402
The dimensions of a denatured protein, fully reduced ribonuclease A (r-RNase A), have been measured using synchrotron-based small angle X-ray scattering. The radius of gyration, 34-35 A, is unchanged from...
6.
Arleth L, Ashok B, Onyuksel H, Thiyagarajan P, Jacob J, Hjelm R
Langmuir
. 2005 Apr;
21(8):3279-90.
PMID: 15807565
Aqueous dispersions of mixed egg yolk phosphatidylcholine (PC) and poly(ethylene glycol) (PEG) modified distearoyl phosphatidylethanolamine (DSPE) were investigated with the purpose of determining shape, size, and conformation of the formed...
7.
Kohn J, Millett I, Jacob J, Zagrovic B, Dillon T, Cingel N, et al.
Proc Natl Acad Sci U S A
. 2004 Aug;
101(34):12491-6.
PMID: 15314214
Spectroscopic studies have identified a number of proteins that appear to retain significant residual structure under even strongly denaturing conditions. Intrinsic viscosity, hydrodynamic radii, and small-angle x-ray scattering studies, in...
8.
Jacob J, Krantz B, Dothager R, Thiyagarajan P, Sosnick T
J Mol Biol
. 2004 Apr;
338(2):369-82.
PMID: 15066438
The dimensions and secondary structure content of two proteins which fold in a two-state manner are measured within milliseconds of denaturant dilution using synchrotron-based, stopped-flow small-angle X-ray scattering and far-UV...
9.
Mehboob S, Jacob J, May M, Kotula L, Thiyagarajan P, Johnson M, et al.
Biochemistry
. 2003 Dec;
42(49):14702-10.
PMID: 14661984
We used SpalphaI-1-156 peptide, a well-characterized model peptide of the alphaN-terminal region of erythrocyte spectrin, and SpalphaII-1-149, an alphaII brain spectrin model peptide similar in sequence to SpalphaI-1-156, to study...
10.
Das R, Kwok L, Millett I, Bai Y, Mills T, Jacob J, et al.
J Mol Biol
. 2003 Sep;
332(2):311-9.
PMID: 12948483
Large RNAs can collapse into compact conformations well before the stable formation of the tertiary contacts that define their final folds. This study identifies likely physical mechanisms driving these early...