J W Backus
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Explore the profile of J W Backus including associated specialties, affiliations and a list of published articles.
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8
Citations
146
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Recent Articles
1.
Steinburg M, Schock D, Backus J, Smith H
Biochem Biophys Res Commun
. 1999 Sep;
263(1):81-6.
PMID: 10486257
Site-specific editing of apolipoprotein B (apoB) mRNA by the cytidine deaminase, APOBEC-1 is proposed to require interactions of auxiliary protein(s) with an eleven nucleotide element, the mooring sequence, located 3'...
2.
Backus J, Schock D, Smith H
Biochim Biophys Acta
. 1994 Sep;
1219(1):1-14.
PMID: 8086446
A 22 nucleotide 'cassette' containing three distinct sequence elements is required for efficient apolipoprotein B (apoB) RNA editing. One of the elements, the mooring sequence, has been proposed as the...
3.
Backus J, Smith H
Biochim Biophys Acta
. 1994 Jan;
1217(1):65-73.
PMID: 8286418
Apolipoprotein B (apoB) mRNA in mammalian intestine undergoes direct conversion of cytidine to uridine at nucleotide 6666, generating a UAA stop codon which defines the carboxyl-terminus of apoB48. We have...
4.
Harris S, Sabio I, Mayer E, STEINBERG M, Backus J, Sparks J, et al.
J Biol Chem
. 1993 Apr;
268(10):7382-92.
PMID: 8463271
The mechanism for tissue-specific differences in apolipoprotein B (apoB) mRNA editing efficiency is not known. Structural data are presented which demonstrate tissue-specific, quantitative differences in the high order complexes containing...
5.
Backus J, Smith H
Nucleic Acids Res
. 1992 Nov;
20(22):6007-14.
PMID: 1461733
Apolipoprotein B (apoB) mRNA is edited in rat liver and intestine to convert a CAA glutamine codon to a UAA translational stop codon by the direct conversion of cytidine to...
6.
Backus J, Smith H
Nucleic Acids Res
. 1991 Dec;
19(24):6781-6.
PMID: 1762908
Apolipoprotein B (apoB) mRNA is edited in rat liver and intestine through the direct conversion of cytidine to uridine at nucleotide 6666. Recently, we have proposed the 'Mooring Sequence' model,...
7.
Smith H, Kuo S, Backus J, Harris S, Sparks C, Sparks J
Proc Natl Acad Sci U S A
. 1991 Feb;
88(4):1489-93.
PMID: 1996349
Specific apolipoprotein B (apoB) mRNA editing can be performed in vitro on apoB RNA substrates. Native gels and glycerol gradient sedimentation have been used to determine the physical properties of...
8.
Backus J, Eagleton M, Harris S, Sparks C, Sparks J, Smith H
Biochem Biophys Res Commun
. 1990 Jul;
170(2):513-8.
PMID: 2383256
The mRNA for apolipoprotein B is translated into either a high molecular weight (apo BH) or low molecular weight (apo BL) form of the protein depending on a novel form...