J W Akkerman
Overview
Explore the profile of J W Akkerman including associated specialties, affiliations and a list of published articles.
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Articles
129
Citations
1005
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Recent Articles
1.
Jupe S, Akkerman J, Soranzo N, Ouwehand W
J Thromb Haemost
. 2012 Sep;
10(11):2399-402.
PMID: 22985186
No abstract available.
2.
Den Dekker E, Gorter G, van der Vuurst H, Heemskerk J, Akkerman J
Thromb Haemost
. 2001 Nov;
86(4):1106-13.
PMID: 11686331
To understand how platelet signal transduction pathways develop during megakaryocytopoiesis, we isolated human stem cells from umbilical cord blood and cultured the cells in the presence of thrombopoietin (TPO). Based...
3.
Den Dekker E, Molin D, Breikers G, van Oerle R, Akkerman J, Van Eys G, et al.
Biochim Biophys Acta
. 2001 Jun;
1539(3):243-55.
PMID: 11420122
Store-regulated Ca(2+) entry (SOCE) is an important mechanism of elevating cytosolic [Ca(2+)]i in platelets, though the Ca(2+) influx channels involved are still unclear. We screened human platelets and their precursor...
4.
Korporaal S, Relou I, van Rijn H, Akkerman J
FEBS Lett
. 2001 Apr;
494(1-2):121-4.
PMID: 11297747
Mildly oxidized low-density lipoprotein activates platelets through lysophosphatidic acid (LPA). Hence, the platelet-activating properties attributed to native low-density lipoprotein (nLDL) might be caused by LPA contamination. We show that nLDL...
5.
van Willigen G, Nieuwland R, Nurnberg B, Gorter G, Akkerman J
Eur J Biochem
. 2000 Dec;
267(24):7102-8.
PMID: 11106421
Human platelets contain a Na+/H+ exchanger (NHE) that regulates the cytosolic pH. The role of trimeric G-proteins in NHE control was investigated in plasma membrane vesicles by measuring exchange of...
6.
Litjens P, Akkerman J, van Willigen G
Platelets
. 2000 Nov;
11(6):310-9.
PMID: 11083455
No abstract available.
7.
Kroner C, Eybrechts K, Akkerman J
J Biol Chem
. 2000 Jun;
275(36):27790-8.
PMID: 10874027
Protein kinase B (PKB) is a serine/threonine kinase that is activated by growth hormones and implicated in prevention of apoptosis, glycogen metabolism, and glucose uptake. A key enzyme in PKB...
8.
Hackeng C, Franke B, Relou I, Gorter G, Bos J, van Rijn H, et al.
Biochem J
. 2000 Jun;
349(Pt 1):231-8.
PMID: 10861233
Physiological concentrations of low-density lipoprotein (LDL) sensitize blood platelets to alpha-thrombin- and collagen-induced secretion, and after prolonged contact trigger secretion independent of other agonists. Here we report that LDL activates...
9.
Hers I, Donath J, Litjens P, van Willigen G, Akkerman J
Arterioscler Thromb Vasc Biol
. 2000 Jun;
20(6):1651-60.
PMID: 10845885
alpha-Thrombin stimulation of human platelets initiates inside-out signaling to integrin alpha(IIb)beta(3) (glycoprotein IIb/IIIa), resulting in the exposure of ligand binding sites. In the present study, the regulation of alpha(IIb)beta(3) via...
10.
van Willigen G, Gorter G, Akkerman J
Thromb Haemost
. 2000 Apr;
83(4):610-6.
PMID: 10780326
Thrombopoietin (TPO) regulates stem cell proliferation and maturation of megakaryocytes by activating the c-Mp1-receptor, a member of the hematopoietic cytokine family. As human platelets possess c-Mp1-receptors and supraphysiological concentrations of...