J Velik
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Explore the profile of J Velik including associated specialties, affiliations and a list of published articles.
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10
Citations
55
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Recent Articles
1.
Skalova L, Krizova V, Cvilink V, Szotakova B, Storkanova L, Velik J, et al.
Vet Parasitol
. 2007 Mar;
146(3-4):254-62.
PMID: 17386978
Parasitic infections can modify the host's ability to metabolize drugs and other xenobiotics by altering the biotransformation enzymes; these changes may have various pharmacological, toxicological or physiological consequences. In our...
2.
Savlik M, Polackova L, Szotakova B, Lamka J, Velik J, Skalova L
Res Vet Sci
. 2007 Feb;
83(1):20-6.
PMID: 17316720
Basal activities of certain pheasant hepatic and intestinal biotransformation enzymes and modulation of their activities by anthelmintics flubendazole (FLBZ) and mebendazole (MBZ) were investigated in subcellular fractions that were prepared...
3.
Velik J, Baliharova V, Skalova L, Szotakova B, Wsol V, Lamka J
J Vet Pharmacol Ther
. 2005 Jul;
28(4):377-84.
PMID: 16050818
Albendazole (ABZ) biotransformation was studied in vitro in liver microsomes of adult noncastrated male farm animals (ram, buck, bull and boar), castrated adult males (wether, billy and hog), and free...
4.
Velik J, Szotakova B, Baliharova V, Lamka J, Savlik M, Wsol V, et al.
Res Vet Sci
. 2005 Mar;
78(3):255-63.
PMID: 15766946
Adult mouflon ewes (Ovis musimon) were treated repeatedly with therapeutic doses of albendazole (ABZ, p.o. 7.5 mg/kg of body weight/day, for five consecutive days). Animals (treated or control) were sacrificed...
5.
Schroterova L, Kaiserova H, Baliharova V, Velik J, Gersl V, Kvasnickova E
Physiol Res
. 2004 Dec;
53(6):683-91.
PMID: 15588138
A major obstacle to the therapeutic use of anthracyclines, highly effective anticancer agents, is the fact that their administration results in dose-dependent cardiomyopathy. According to the currently accepted hypothesis, anthracyclines...
6.
Baliharova V, Velik J, Savlik M, Szotakova B, Lamka J, Tahotna L, et al.
J Vet Pharmacol Ther
. 2004 Apr;
27(2):85-90.
PMID: 15096105
Fenbendazole (FBZ), flubendazole (FLBZ) and mebendazole (MBZ) are benzimidazole anthelmintics widely used in veterinary medicine. The effects of these drugs on cytochromes P450 (CYP) were investigated in primary cultures of...
7.
Velik J, Baliharova V, Fink-Gremmels J, Bull S, Lamka J, Skalova L
Res Vet Sci
. 2003 Dec;
76(2):95-108.
PMID: 14672851
Benzimidazole drugs (e.g., anthelmintics albendazole, fenbendazole, oxfenbendazole, thiabendazole, mebendazole; inhibitors of proton pump omeprazole, lansoprasole, pantoprasole) represent substances used in both human and veterinary medicine; however, from the point of...
8.
Szotakova B, Baliharova V, Lamka J, Nozinova E, Wsol V, Velik J, et al.
Res Vet Sci
. 2003 Dec;
76(1):43-51.
PMID: 14659728
In vitro activities of cytochromes P450 (7-alkyl/aryloxyresorufin dealkyl(aryl)ases, testosterone hydroxylase/oxidase, 6-chlorzoxazone hydroxylase, 7-methoxy-4-trifluoromethyl-coumarin demethylase, and lauric acid hydroxylases), reductases of carbonyl group (toward metyrapone, daunorubicin, glyceraldehyde, and 4-pyridine-carboxaldehyde) and conjugation...
9.
Baliharova V, Velik J, Lamka J, Balarinova R, Skalova L
Res Vet Sci
. 2003 Sep;
75(3):231-9.
PMID: 13129672
Albendazole (ABZ) is a benzimidazole anthelmintic widely used in veterinary medicine. The effects of ABZ on cytochromes P450 were investigated in primary cultures of mouflon (Ovis musimon) and rat (Rattus...
10.
Velik J, Baliharova V, Skalova L, Szotakova B, Wsol V, Lamka J
J Vet Pharmacol Ther
. 2003 Jul;
26(4):297-302.
PMID: 12887613
The anthelmintic albendazole (ABZ) undergoes a two-step oxidation resulting first in the formation of chiral albendazole sulfoxide (ABZSO) followed by its transformation to albendazole sulfone (ABZSO2) in many farm and...