J U Gutterman
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Explore the profile of J U Gutterman including associated specialties, affiliations and a list of published articles.
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333
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3619
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Recent Articles
1.
Xu Z, Liang J, Haridas V, Gaikwad A, Connolly F, Mills G, et al.
Cell Death Differ
. 2007 Aug;
14(11):1948-57.
PMID: 17690712
Avicins, a family of plant triterpene electrophiles, can trigger apoptosis-associated tumor cell death, and suppress chemical-induced carcinogenesis by its anti-inflammatory, anti-mutagenic, and antioxidant properties. Here, we show that tumor cells...
2.
Haridas V, Arntzen C, Gutterman J
Proc Natl Acad Sci U S A
. 2001 Sep;
98(20):11557-62.
PMID: 11572998
Triterpenoid saponins, which are present in leguminous plants and some marine animals, possess a broad range of biological actions. We have earlier reported the extraction of avicins, a family of...
3.
Hanausek M, Ganesh P, Walaszek Z, Arntzen C, Slaga T, Gutterman J
Proc Natl Acad Sci U S A
. 2001 Sep;
98(20):11551-6.
PMID: 11572997
We tested the ability of avicins, a family of triterpenoid saponins obtained from Acacia victoriae (Bentham) (Leguminosae: Mimosoideae), to inhibit chemically induced mouse skin carcinogenesis. Varying doses of avicins were...
4.
Mujoo K, Haridas V, Hoffmann J, Wachter G, Hutter L, Lu Y, et al.
Cancer Res
. 2001 Jul;
61(14):5486-90.
PMID: 11454696
This report describes the isolation and partial purification of novel triterpenoid saponins [Fraction 35 (F035)] and two pure biologically active derivatives (termed avicins D and G) from Acacia victoriae, an...
5.
Logothetis C, Wu K, Finn L, Daliani D, Figg W, Ghaddar H, et al.
Clin Cancer Res
. 2001 May;
7(5):1198-203.
PMID: 11350884
Clinical and laboratory observations support the view that angiogenesis is necessary for prostate cancer progression. The angiogenesis inhibitor TNP-470 has demonstrated in vivo antitumor activity in a series of clinical...
6.
Haridas V, Higuchi M, Jayatilake G, Bailey D, Mujoo K, Blake M, et al.
Proc Natl Acad Sci U S A
. 2001 May;
98(10):5821-6.
PMID: 11344312
Anticancer agents target various subcellular components and trigger apoptosis in chemosensitive cells. We have recently reported the tumor cell growth inhibitory properties of a mixture of triterpenoid saponins obtained from...
7.
Retardation of cell proliferation after expression of p202 accompanies an increase in p21(WAF1/CIP1)
Gutterman J, Choubey D
Cell Growth Differ
. 1999 Mar;
10(2):93-100.
PMID: 10074903
p202 is an IFN-inducible, primarily nuclear, phosphoprotein (52-kDa) whose constitutive overexpression in transfected cells inhibits colony formation. To investigate the molecular mechanism(s) by which expression of p202 protein impairs colony...
8.
Yan D, Wen Y, Spohn B, Choubey D, Gutterman J, Hung M
Oncogene
. 1999 Feb;
18(3):807-11.
PMID: 9989832
Interferons (IFNs) can exert cytostatic and immunomodulatory effects on carcinoma cells. In particular, growth inhibition of human prostate carcinoma by IFNs has been demonstrated both in vitro and in vivo....
9.
Koul D, Obeyesekere N, Gutterman J, Mills G, Choubey D
FEBS Lett
. 1998 Nov;
438(1-2):21-4.
PMID: 9821952
Murine p202 is an interferon-inducible primarily nuclear phosphoprotein (52 kDa) whose expression in transfected cells inhibits colony formation. p202-binding proteins include the pocket proteins (pRb, p107 and p130), a p53-binding...
10.
A phase I study of TNP-470 administered to patients with advanced squamous cell cancer of the cervix
Kudelka A, Levy T, Verschraegen C, Edwards C, Piamsomboon S, Termrungruanglert W, et al.
Clin Cancer Res
. 1998 Nov;
3(9):1501-5.
PMID: 9815836
A Phase I study of the novel angiogenesis inhibitor TNP-470 was performed. Patients with inoperable recurring or metastatic squamous cell cancer of the cervix with evaluable disease, no coagulopathy, and...