J T Reardon
Overview
Explore the profile of J T Reardon including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
29
Citations
1660
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
George J, Salazar E, Vreeswijk M, Lamerdin J, Reardon J, Zdzienicka M, et al.
Mol Cell Biol
. 2001 Oct;
21(21):7355-65.
PMID: 11585917
The UV-sensitive V-H1 cell line has a T46I substitution mutation in the Walker A box in both alleles of XPD and lacks DNA helicase activity. We characterized three partial revertants...
2.
Branum M, Reardon J, Sancar A
J Biol Chem
. 2001 May;
276(27):25421-6.
PMID: 11353769
Nucleotide excision repair is a general repair system that eliminates many dissimilar lesions from DNA. In an effort to understand substrate determinants of this repair system, we tested DNAs with...
3.
Shibutani S, Reardon J, Suzuki N, Sancar A
Cancer Res
. 2000 May;
60(10):2607-10.
PMID: 10825130
The antiestrogen tamoxifen is used in the treatment of breast cancer and has recently been recommended as a chemopreventive drug for women at high risk for breast cancer. However, women...
4.
Reardon J, Vaisman A, Chaney S, Sancar A
Cancer Res
. 1999 Aug;
59(16):3968-71.
PMID: 10463593
Tumors exhibit a spectrum of cellular responses to chemotherapy ranging from extreme sensitivity to resistance, either intrinsic or acquired. These variable responses are both patient and tumor specific. For platinum...
5.
Grant D, Bessho T, Reardon J
Cancer Res
. 1998 Nov;
58(22):5196-200.
PMID: 9823332
The nucleotide-excision repair (NER) system removes bulky DNA adducts and is thought to be involved in resistance to chemotherapeutic drugs, which act by damaging DNA. In this study, we have...
6.
Khan S, Levy H, LEGERSKI R, Quackenbush E, Reardon J, Emmert S, et al.
J Invest Dermatol
. 1998 Nov;
111(5):791-6.
PMID: 9804340
A 4 y old boy of Korean ancestry had xeroderma pigmentosum (XP) with sun sensitivity, multiple cutaneous neoplasms, and inability to speak. Neurologic examination revealed hyperactivity and autistic features without...
7.
Reardon J, Bessho T, Kung H, Bolton P, Sancar A
Proc Natl Acad Sci U S A
. 1997 Aug;
94(17):9463-8.
PMID: 9256505
Xeroderma pigmentosum (XP) patients fail to remove pyrimidine dimers caused by sunlight and, as a consequence, develop multiple cancers in areas exposed to light. The second most common sign, present...
8.
Wakasugi M, Reardon J, Sancar A
J Biol Chem
. 1997 Jun;
272(25):16030-4.
PMID: 9188507
XPG is a member of the FEN-1 structure-specific endonuclease family. It has 3'-junction cutting activity on bubble substrates and makes the 3'-incision in the human dual incision (excision nuclease) repair...
9.
Reardon J, Thompson L, Sancar A
Nucleic Acids Res
. 1997 Mar;
25(5):1015-21.
PMID: 9023113
Mammalian nucleotide excision repair is the primary enzymatic pathway for removing bulky lesions from DNA. The repair reaction involves three main steps: (i) dual incisions on both sides of the...
10.
Brookman K, Lamerdin J, Thelen M, Hwang M, Reardon J, Sancar A, et al.
Mol Cell Biol
. 1996 Nov;
16(11):6553-62.
PMID: 8887684
ERCC4 is an essential human gene in the nucleotide excision repair (NER) pathway, which is responsible for removing UV-C photoproducts and bulky adducts from DNA. Among the NER genes, ERCC4...