J Seshu
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Explore the profile of J Seshu including associated specialties, affiliations and a list of published articles.
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37
Citations
1136
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Recent Articles
1.
Kumaresan V, Hung C, Hermann B, Seshu J
bioRxiv
. 2024 Nov;
PMID: 39605372
, the spirochetal agent of Lyme disease, has a large array of lipoproteins that play a significant role in mediating host-pathogen interactions within ticks and vertebrates. Although there is substantial...
2.
Moy B, Seshu J
Front Cell Infect Microbiol
. 2021 Jul;
11:679982.
PMID: 34235094
Sulfate Transport Anti-Sigma antagonist domains (Pfam01740) are found in all branches of life, from eubacteria to mammals, as a conserved fold encoded by highly divergent amino acid sequences. These domains...
3.
Seshu J, Moy B, Ingle T
Curr Protoc
. 2021 Mar;
1(3):e61.
PMID: 33661557
Transformation techniques used to genetically manipulate Borrelia burgdorferi, the agent of Lyme disease, play a critical role in generating mutants that facilitate analyses of the role of genes in the...
4.
ONeill L, Keane O, Ross P, Nally J, Seshu J, Markey B
Vaccine
. 2019 Aug;
37(36):5428-5438.
PMID: 31375438
MIP and CPAF from Chlamydia have been shown to be effective in inducing immune responses important in clearing chlamydial infections. This study evaluates the protection conferred by MIP and CPAF...
5.
Ketter P, Yu J, Guentzel M, May H, Gupta R, Eppinger M, et al.
mBio
. 2018 Jul;
9(4).
PMID: 29991584
Multidrug-resistant is among the most common causes of infectious complications associated with combat-related trauma in military personnel serving overseas. However, little is currently known about its pathogenesis. While the gastrointestinal...
6.
Lin Y, Chen Y, Smith 2nd T, Karna S, Seshu J
Infect Immun
. 2018 Jun;
86(9).
PMID: 29891543
responds to a variety of host-derived factors and appropriately alters its gene expression for adaptation under different host-specific conditions. We previously showed that various levels of acetate, a short-chain fatty...
7.
Smith 2nd T, Helm S, Chen Y, Lin Y, Karna S, Seshu J
Infect Immun
. 2018 Apr;
86(7).
PMID: 29685985
, the agent of Lyme disease (LD), uses host-derived signals to modulate gene expression during the vector and mammalian phases of infection. Microarray analysis of mutants lacking the host aptation...
8.
Seshu J, Smith 2nd T, Lin Y, Karna S, Miller C, Van Laar T
Methods Mol Biol
. 2017 Oct;
1690:155-175.
PMID: 29032544
Bioinformatic approaches and a large volume of prokaryotic genome sequences have enabled rapid identification of regulatory proteins with features to bind DNA or RNA in a given prokaryote. However, biological...
9.
Lin Y, Romo J, Smith 2nd T, Reyes A, Karna S, Miller C, et al.
Infect Immun
. 2017 Jan;
85(3).
PMID: 28052993
, the agent of Lyme disease, responds to numerous host-derived signals to alter adaptive capabilities during its enzootic cycle in an arthropod vector and mammalian host. Molecular mechanisms that enable...
10.
Van Laar T, Hole C, Karna S, Miller C, Reddick R, Wormley F, et al.
Microbes Infect
. 2016 Mar;
18(6):430-435.
PMID: 26993029
Lyme disease (LD) is a systemic disorder caused by Borrelia burgdorferi. Lyme spirochetes encode for a functional 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR EC 1.1.1.88) serving as a rate limiting enzyme of...