J Scott Edgar
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Explore the profile of J Scott Edgar including associated specialties, affiliations and a list of published articles.
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20
Citations
413
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Recent Articles
11.
Kuo J, Ng L, Yen G, Lorenz R, Schiro P, Edgar J, et al.
Lab Chip
. 2009 Mar;
9(7):870-6.
PMID: 19294296
As microfluidic systems transition from research tools to disposable clinical-diagnostic devices, new substrate materials are needed to meet both the regulatory requirement as well as the economics of disposable devices....
12.
Edgar J, Milne G, Zhao Y, Pabbati C, Lim D, Chiu D
Angew Chem Int Ed Engl
. 2009 Jan;
48(15):2719-22.
PMID: 19142923
Not merely a drop in the ocean: The integration of capillary electrophoresis (CE) with droplet generation driven by electroosmotic flow enabled the compartimentalization of molecular components separated by CE in...
13.
Allen P, Sgro A, Chao D, Doepker B, Edgar J, Shen K, et al.
J Neurosci Methods
. 2008 Jun;
173(1):20-6.
PMID: 18579213
Synapses are individually operated, computational units for neural communication. To manipulate physically individual synapses in a living organism, we have developed a laser ablation technique for removing single synapses in...
14.
Zhao Y, Edgar J, Jeffries G, McGloin D, Chiu D
Phys Rev Lett
. 2007 Oct;
99(7):073901.
PMID: 17930896
As a fundamental property of light, the angular momentum of photons has been of great interest. Here, we demonstrate that optical spin-to-orbital angular momentum conversion can occur in a homogeneous...
15.
Jeffries G, Edgar J, Zhao Y, Shelby J, Fong C, Chiu D
Nano Lett
. 2007 Feb;
7(2):415-20.
PMID: 17298009
Single-cell nanosurgery and the ability to manipulate nanometer-sized subcellular structures with optical tweezers has widespread applications in biology but so far has been limited by difficulties in maintaining the functionality...
16.
Lorenz R, Edgar J, Jeffries G, Zhao Y, McGloin D, Chiu D
Anal Chem
. 2006 Dec;
79(1):224-8.
PMID: 17194143
This paper describes the use of an optical vortex trap for the transport and fusion of single femtoliter-volume aqueous droplets. Individual droplets were generated by emulsifying water in acetophenone with...
17.
Edgar J, Pabbati C, Lorenz R, He M, Fiorini G, Chiu D
Anal Chem
. 2006 Sep;
78(19):6948-54.
PMID: 17007519
This paper demonstrates the ability to use capillary electrophoresis (CE) separation coupled with laser-induced fluorescence for analyzing the contents of single femtoliter-volume aqueous droplets. A single droplet was formed using...
18.
Lorenz R, Edgar J, Jeffries G, Chiu D
Anal Chem
. 2006 Sep;
78(18):6433-9.
PMID: 16970318
This paper describes a fluidic and optical platform for the generation and manipulation of single femtoliter-volume aqueous droplets. Individual droplets were generated on-demand using a microfluidic chamber that confers environmental...
19.
Shelby J, Edgar J, Chiu D
Photochem Photobiol
. 2005 Apr;
81(4):994-1001.
PMID: 15850426
This paper characterizes cell viability in three different cell lines--Chinese hamster ovary cells (CHO), neuroblastoma cells fused with glialoma cells (NG108-15) and murine embryonic stem cells (ES-D3)--after N2 laser disruption...
20.
He M, Edgar J, Jeffries G, Lorenz R, Shelby J, Chiu D
Anal Chem
. 2005 Mar;
77(6):1539-44.
PMID: 15762555
This paper describes a method, which combines optical trapping and microfluidic-based droplet generation, for selectively and controllably encapsulating a single target cell or subcellular structure, such as a mitochondrion, into...