J Rizo
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Explore the profile of J Rizo including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
2730
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Recent Articles
1.
Rhee J, Li L, Shin O, Rah J, Rizo J, Sudhof T, et al.
Proc Natl Acad Sci U S A
. 2005 Dec;
102(51):18664-9.
PMID: 16352718
Synaptotagmin 1 likely acts as a Ca2+ sensor in neurotransmitter release by Ca2+-binding to its two C2 domains. This notion was strongly supported by the observation that a mutation in...
2.
Fernandez I, Arac D, Ubach J, Gerber S, Shin O, Gao Y, et al.
Neuron
. 2002 Jan;
32(6):1057-69.
PMID: 11754837
Synaptotagmin 1 probably functions as a Ca2+ sensor in neurotransmitter release via its two C2-domains, but no common Ca2+-dependent activity that could underlie a cooperative action between them has been...
3.
Gerber S, Rizo J, Sudhof T
J Biol Chem
. 2001 Jul;
276(34):32288-92.
PMID: 11447211
The phospholipid-binding specificities of C(2) domains, widely distributed Ca(2+)-binding modules, differ greatly despite similar three-dimensional structures. To understand the molecular basis for this specificity, we have examined the synaptotagmin 1...
4.
Ubach J, Lao Y, Fernandez I, Arac D, Sudhof T, Rizo J
Biochemistry
. 2001 May;
40(20):5854-60.
PMID: 11352720
Synaptotagmin I is a synaptic vesicle protein that contains two C(2) domains and acts as a Ca(2+) sensor in neurotransmitter release. The Ca(2+)-binding properties of the synaptotagmin I C(2)A domain...
5.
Wang Y, Dulubova I, Rizo J, Sudhof T
J Biol Chem
. 2001 May;
276(30):28598-605.
PMID: 11349128
Vam3p, a syntaxin-like SNARE protein involved in yeast vacuole fusion, is composed of a three-helical N-terminal domain, a canonical SNARE motif, and a C-terminal transmembrane region (TMR). Surprisingly, we find...
6.
Gerber S, Garcia J, Rizo J, Sudhof T
EMBO J
. 2001 Apr;
20(7):1605-19.
PMID: 11285225
Ca(2+) regulation of neurotransmitter release is thought to require multiple Ca(2+) sensors with distinct affinities. However, no low-affinity Ca(2+) sensor has been identified at the synapse. We now show that...
7.
Fernandez-Chacon R, Konigstorfer A, Gerber S, Garcia J, Matos M, Stevens C, et al.
Nature
. 2001 Mar;
410(6824):41-9.
PMID: 11242035
In all synapses, Ca2+ triggers neurotransmitter release to initiate signal transmission. Ca2+ presumably acts by activating synaptic Ca2+ sensors, but the nature of these sensors--which are the gatekeepers to neurotransmission--remains...
8.
Dulubova I, Yamaguchi T, Wang Y, Sudhof T, Rizo J
Nat Struct Biol
. 2001 Feb;
8(3):258-64.
PMID: 11224573
Syntaxins and Sec1/munc18 proteins are central to intracellular membrane fusion. All syntaxins comprise a variable N-terminal region, a conserved SNARE motif that is critical for SNARE complex formation, and a...
9.
Matos M, Rizo J, Sudhof T
Eur J Cell Biol
. 2000 Aug;
79(6):377-82.
PMID: 10928452
The Q-SNARE syntaxin 1 is a central component of the synaptic membrane fusion machinery. Syntaxin probably interacts with multiple proteins during synaptic vesicle exocytosis. In vitro, the tightest binding partners...
10.
Pabst S, Hazzard J, Antonin W, Sudhof T, Jahn R, Rizo J, et al.
J Biol Chem
. 2000 Apr;
275(26):19808-18.
PMID: 10777504
Complexins are evolutionarily conserved proteins that specifically bind to soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes and thus may regulate SNARE function. Using purified proteins, we have performed a...