J R Wyer
Overview
Explore the profile of J R Wyer including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
512
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0
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Recent Articles
1.
Gao G, Willcox B, Wyer J, Boulter J, OCallaghan C, Maenaka K, et al.
J Biol Chem
. 2000 May;
275(20):15232-8.
PMID: 10809759
The cell surface molecules CD4 and CD8 greatly enhance the sensitivity of T-cell antigen recognition, acting as "co-receptors" by binding to the same major histocompatibility complex (MHC) molecules as the...
2.
Willcox B, Gao G, Wyer J, OCallaghan C, Boulter J, Jones E, et al.
Protein Sci
. 1999 Dec;
8(11):2418-23.
PMID: 10595544
A method to produce alphabeta T-cell receptors (TCRs) in a soluble form suitable for biophysical analysis was devised involving in vitro refolding of a TCR fusion protein. Polypeptides corresponding to...
3.
Maenaka K, Juji T, Nakayama T, Wyer J, Gao G, Maenaka T, et al.
J Biol Chem
. 1999 Sep;
274(40):28329-34.
PMID: 10497191
Human natural killer cells and a subset of T cells express a repertoire of killer cell immunoglobulin receptors (KIRs) that recognize major histocompatibility complex (MHC) class I molecules. KIRs and...
4.
Willcox B, Gao G, Wyer J, Ladbury J, Bell J, Jakobsen B, et al.
Immunity
. 1999 Apr;
10(3):357-65.
PMID: 10204491
The binding of TCRs to their peptide-MHC ligands is characterized by a low affinity, slow kinetics, and a high degree of cross-reactivity. Here, we report the results of a kinetic...
5.
Wyer J, Willcox B, Gao G, Gerth U, Davis S, Bell J, et al.
Immunity
. 1999 Mar;
10(2):219-25.
PMID: 10072074
The T cell surface glycoprotein CD8 enhances T cell antigen recognition by binding to MHC class I molecules. We show that human CD8 alphaalpha binds to the MHC class I...
6.
OCallaghan C, Byford M, Wyer J, Willcox B, Jakobsen B, McMichael A, et al.
Anal Biochem
. 1999 Jan;
266(1):9-15.
PMID: 9887208
The enzyme BirA is a key reagent because of its ability to biotinylate proteins at a specific residue in a recognition sequence. We report a rapid, efficient, and economical method...
7.
Gao G, Gerth U, Wyer J, Willcox B, OCallaghan C, Zhang Z, et al.
Protein Sci
. 1998 May;
7(5):1245-9.
PMID: 9605330
A strategy for overexpression in Escherichia coli of the extracellular immunoglobulin domain of human CD8alpha was devised using codon usage alterations in the 5' region of the gene, designed so...
8.
Gao G, Tormo J, Gerth U, Wyer J, McMichael A, Stuart D, et al.
Nature
. 1997 Jun;
387(6633):630-4.
PMID: 9177355
The dimeric cell-surface glycoprotein CD8 is crucial to the positive selection of cytotoxic T cells in the thymus. The homodimer CD8alpha(alpha) or the heterodimer alpha beta stabilizes the interaction of...