J R Mendell
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Explore the profile of J R Mendell including associated specialties, affiliations and a list of published articles.
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203
Citations
4626
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Recent Articles
1.
Pozsgai E, Griffin D, Heller K, Mendell J, Rodino-Klapac L
Gene Ther
. 2015 Jul;
23(1):57-66.
PMID: 26214262
Limb-girdle muscular dystrophy type 2E (LGMD2E) results from mutations in the β-sarcoglycan (SGCB) gene causing loss of functional protein and concomitant loss of dystrophin-associated proteins. The disease phenotype is characterized...
2.
Yalvac M, Arnold W, Braganza C, Chen L, Mendell J, Sahenk Z
Gene Ther
. 2015 Jul;
23(1):95-102.
PMID: 26125608
The spontaneous autoimmune peripheral polyneuropathy (SAPP) model in B7-2 knockout non-obese diabetic mice shares clinical and histological features with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Secondary axonal loss is prominent in...
3.
Alfano L, Lowes L, Dvorchik I, Yin H, Maus E, Flanigan K, et al.
Neuromuscul Disord
. 2013 Dec;
24(3):222-6.
PMID: 24342281
Sporadic inclusion body myositis causes progressive functional loss due to declining muscle strength. Although the underlying cause is unknown, clinical trials are underway to improve strength and function. Selection of...
4.
Chicoine L, Montgomery C, Bremer W, Shontz K, Griffin D, Heller K, et al.
Mol Ther
. 2013 Nov;
22(2):338-347.
PMID: 24196577
Duchenne muscular dystrophy is a monogenic disease potentially treatable by gene replacement. Use of recombinant adeno-associated virus (AAV) will ultimately require a vascular approach to broadly transduce muscle cells. We...
5.
Lack of toxicity of alpha-sarcoglycan overexpression supports clinical gene transfer trial in LGMD2D
Rodino-Klapac L, Lee J, Mulligan R, Clark K, Mendell J
Neurology
. 2008 Jun;
71(4):240-7.
PMID: 18525034
Background: Alpha-sarcoglycan (alpha-SG) deficiency (limb-girdle muscular dystrophy [LGMD] type 2D) is the most common form of sarcoglycan-LGMD. No treatment is currently available. Prior studies suggest that overexpression of alpha-SG via...
6.
King W, Ruttencutter R, Nagaraja H, Matkovic V, Landoll J, Hoyle C, et al.
Neurology
. 2007 May;
68(19):1607-13.
PMID: 17485648
Objective: To document the effects of long-term daily corticosteroid treatment on a variety of orthopedic outcomes in boys with Duchenne muscular dystrophy. Methods: We reviewed the charts of 159 boys...
7.
Tsao C, Mendell J
J Child Neurol
. 2006 Mar;
21(2):148-50.
PMID: 16566880
Muscular dystrophies are composed of a variety of genetic muscle disorders linked to different chromosomes and loci and associated with different gene mutations that lead to progressive muscle atrophy and...
8.
Barohn R, Herbelin L, Kissel J, King W, McVey A, Saperstein D, et al.
Neurology
. 2006 Jan;
66(2 Suppl 1):S123-4.
PMID: 16432140
Inclusion-body myositis (IBM) is an inflammatory muscle disease that has proven resistant to treatment. Tumor necrosis factor molecules have been detected in muscle biopsies from patients with IBM. Etanercept is...
9.
Sahenk Z, Nagaraja H, McCracken B, King W, Freimer M, Cedarbaum J, et al.
Neurology
. 2005 Sep;
65(5):681-9.
PMID: 16157899
Background: Xenografts from patients with Charcot-Marie-Tooth type 1A (CMT1A) have shown delayed myelination and impaired regeneration of nude mice axons passing through the grafted segments. Neurotrophin-3 (NT-3), an important component...
10.
Miller T, Dias da Silva M, Miller H, Kwiecinski H, Mendell J, Tawil R, et al.
Neurology
. 2004 Nov;
63(9):1647-55.
PMID: 15534250
Background: Periodic paralyses and paramyotonia congenita are rare disorders causing disabling weakness and myotonia. Mutations in sodium, calcium, and potassium channels have been recognized as causing disease. Objective: To analyze...