J R Hatherill
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Explore the profile of J R Hatherill including associated specialties, affiliations and a list of published articles.
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17
Citations
153
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Recent Articles
1.
Builee T, Hatherill J
Drug Chem Toxicol
. 2004 Dec;
27(4):405-24.
PMID: 15573475
Thyroid hormones (TH) are essential to normal brain development, influencing behavior and cognitive function in both adult and children. It is suggested that conditions found in TH abnormalities such as...
2.
Yonemaru M, Hatherill J, Hoffmann H, Zheng H, Ishii K, Raffin T
J Appl Physiol (1985)
. 1991 Jul;
71(1):342-51.
PMID: 1655691
Pentoxifylline (PTX), a methylxanthine, can suppress polymorphonuclear leukocyte (PMN) activation and attenuate sepsis-induced acute lung injury. We investigated whether PTX prevents non-PMN-dependent lung injury. First we studied four groups of...
3.
Hatherill J, Till G, Ward P
Agents Actions
. 1991 Mar;
32(3-4):351-8.
PMID: 1862753
There is an increasing body of experimental studies demonstrating the toxic effects of oxygen-derived free radicals. Evidence supports an important role for free radicals in ischemic injuries, inflammation, and chemical-induced...
4.
Hoffmann H, Hatherill J, Crowley J, Harada H, Yonemaru M, Zheng H, et al.
Am Rev Respir Dis
. 1991 Feb;
143(2):289-93.
PMID: 1846727
We examined effects of early post-treatment with the methylxanthine pentoxifylline (PTXF), or the cell-permeable adenosine 3', 5'-cyclic monophosphate (cAMP) analog dibutyryl cAMP (db-cAMP) on Escherichia-coli-induced acute lung injury in guinea...
5.
Zheng H, Crowley J, Chan J, Hoffmann H, Hatherill J, Ishizaka A, et al.
Am Rev Respir Dis
. 1990 Nov;
142(5):1073-8.
PMID: 2173454
Our laboratory has previously shown that the administration of tumor necrosis factor (TNF), a cytokine produced by activated mononuclear cells, to guinea pigs produces a syndrome similar to gram-negative sepsis...
6.
Ishizaka A, Stephens K, Segall G, Hatherill J, McDougall I, Wu Z, et al.
Am Rev Respir Dis
. 1990 Mar;
141(3):631-9.
PMID: 2178527
The individual roles of pulmonary capillary endothelial and alveolar epithelial permeability in the pathogenesis of the adult respiratory distress syndrome (ARDS) are unclear. We developed a method for the sequential...
7.
8.
Ishizaka A, Hatherill J, Harada H, Yonemaru M, Hoffmann H, Zheng H, et al.
J Appl Physiol (1985)
. 1989 Dec;
67(6):2432-7.
PMID: 2606851
We administered recombinant human interleukin 2 (IL-2) to guinea pigs to investigate whether IL-2 would cause acute lung injury. In addition, we examined the effects of pentoxifylline (PTXF) on IL-2-induced...
9.
Hatherill J, Stephens K, Nagao K, Ishizaka A, Wilmarth L, Wang J, et al.
J Biol Response Mod
. 1989 Dec;
8(6):614-24.
PMID: 2600603
Previous investigation has demonstrated that in vivo complement activation can produce acute lung injury. Complement component C5a has been implicated as a key factor in this damage. In addition, C5a...
10.
Yonemaru M, Stephens K, Ishizaka A, Zheng H, Hogue R, Crowley J, et al.
J Lab Clin Med
. 1989 Dec;
114(6):674-81.
PMID: 2592855
Tumor necrosis factor (TNF) has been proposed as an important mediator of the inflammatory response in acute lung injury. To better understand polymorphonuclear leukocyte (PMN) activation during acute lung injury,...