J R Hamilton
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Explore the profile of J R Hamilton including associated specialties, affiliations and a list of published articles.
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200
Citations
1590
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Recent Articles
1.
Larsson P, Tarlac V, Wang T, Bonnard T, Hagemeyer C, Hamilton J, et al.
Sci Rep
. 2022 Mar;
12(1):3955.
PMID: 35273275
Vascular injury models are indispensable for studying thrombotic processes in vivo. Amongst the available methods for inducing thrombosis, laser-induced endothelial injury (LIEI) has several unique advantages. However, a lack of...
2.
Castilho L, Nance S, Hamilton J
Immunohematology
. 2021 Sep;
37(3):1-4.
PMID: 34591382
No abstract available.
3.
French S, Arthur J, Lee H, Nesbitt W, Andrews R, Gardiner E, et al.
J Thromb Haemost
. 2016 Feb;
14(8):1642-54.
PMID: 26878340
Unlabelled: Essentials The platelet thrombin receptor, PAR4, is an emerging anti-thrombotic drug target. We examined the anti-platelet & anti-thrombotic effects of PAR4 inhibition in human blood. PAR4 inhibition impaired platelet...
4.
Hamilton J, Sunter J, Cooper P
Forensic Sci Med Pathol
. 2015 Apr;
1(4):267-71.
PMID: 25868445
Scalp lacerations are frequently seen in both living trauma victims and at post-mortem examination. In clinical circles, it is well known that even "trivial" lacerations of blood-rich areas such as...
5.
Lee H, Sturgeon S, Mountford J, Jackson S, Hamilton J
Br J Pharmacol
. 2012 Mar;
166(7):2188-97.
PMID: 22428607
Background And Purpose: Developing novel anti-platelet strategies is fundamental to reducing the impact of thrombotic diseases. Thrombin activates platelets via proteinase-activated receptors (PARs), and PAR antagonists are being evaluated in...
6.
Takiguchi M, James C, Josefsson E, Carmichael C, Premsrirut P, Lowe S, et al.
J Thromb Haemost
. 2010 Dec;
8(12):2751-6.
PMID: 21138522
Background: RNA interference (RNAi) is a powerful tool for suppressing gene function. The tetracycline (tet)-regulated expression system has recently been adapted to allow inducible RNAi in mice, however its efficiency...
7.
Hamilton J
Can Fam Physician
. 2010 May;
19(11):72-5.
PMID: 20468999
Conventional concepts of daily vitamin requirements may need revision. For example, recent studies on Vitamin C suggest that the recommended daily allowance, while it certainly prevents scurvy, may not saturate...
8.
Hamilton J, Cornelissen I, Mountford J, Coughlin S
Atherosclerosis
. 2009 Feb;
205(2):427-32.
PMID: 19217621
Platelet activation has long been postulated to contribute to the development of atherosclerotic plaques, although the mechanism by which this might occur remains unknown. Thrombin is a potent platelet activator...
9.
Hamilton J, Cornelissen I, Coughlin S
J Thromb Haemost
. 2004 Aug;
2(8):1429-35.
PMID: 15304051
Platelets from protease-activated receptor 4 (PAR4)-deficient mice are unresponsive to thrombin, and Par4-/- mice have prolonged bleeding times and are protected against thrombosis. However, in addition to its role in...
10.
Wong C, Mason K, Hamilton J, Hasan A
Ann Thorac Surg
. 2001 Nov;
72(5):1800-1.
PMID: 11722111
No abstract available.