J P Luzio
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Explore the profile of J P Luzio including associated specialties, affiliations and a list of published articles.
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124
Citations
2837
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Recent Articles
1.
Luzio J, Bright N, Pryor P
Biochem Soc Trans
. 2007 Oct;
35(Pt 5):1088-91.
PMID: 17956286
The passage of endocytosed receptor-bound ligands and membrane proteins through the endocytic pathway of mammalian cells to lysosomes occurs via early and late endosomes. The latter contain many luminal vesicles...
2.
Buss F, Luzio J, Kendrick-Jones J
FEBS Lett
. 2001 Dec;
508(3):295-9.
PMID: 11728438
The integrity of the actin cytoskeleton and associated motor proteins are essential for the efficient functioning of clathrin mediated endocytosis at least in polarised cells. Myosin VI, the only motor...
3.
Ihrke G, Bruns J, Luzio J, Weisz O
EMBO J
. 2001 Nov;
20(22):6256-64.
PMID: 11707397
We have examined the trafficking of the mucin-like protein endolyn in transfected, polarized MDCK cells using biochemical approaches and immunofluorescence microscopy. Although endolyn contains a lysosomal targeting motif of the...
4.
Bright N, Lindsay M, Stewart A, Luzio J
Traffic
. 2001 Sep;
2(9):631-42.
PMID: 11555417
Immunofluorescence and electron microscopy were used to evaluate the formation of swollen endosomes in NRK cells after treatment with wortmannin or sucrose and to study the relationship between lumenal and...
5.
Piper R, Luzio J
Traffic
. 2001 Sep;
2(9):612-21.
PMID: 11555415
Late endosomes, which have the morphological characteristics of multivesicular bodies, have received relatively little attention in comparison with early endosomes and lysosomes. Recent work in mammalian and yeast cells has...
6.
Luzio J, Mullock B, Pryor P, Lindsay M, James D, Piper R
Biochem Soc Trans
. 2001 Aug;
29(Pt 4):476-80.
PMID: 11498012
Delivery of endocytosed macromolecules to lysosomes occurs by means of direct fusion of late endosomes with lysosomes. This has been formally demonstrated in a cell-free content mixing assay using late...
7.
Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis
Buss F, Arden S, Lindsay M, Luzio J, Kendrick-Jones J
EMBO J
. 2001 Jul;
20(14):3676-84.
PMID: 11447109
Myosin VI is involved in membrane traffic and dynamics and is the only myosin known to move towards the minus end of actin filaments. Splice variants of myosin VI with...
8.
Wade N, Bryant N, Connolly L, Simpson R, Luzio J, Piper R, et al.
J Biol Chem
. 2001 Mar;
276(23):19820-7.
PMID: 11278762
Syntaxin 7 is a mammalian target soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) involved in membrane transport between late endosomes and lysosomes. The aim of the present study was to...
9.
Macary P, Lindsay M, Scott M, Craig J, Luzio J, Lehner P
Proc Natl Acad Sci U S A
. 2001 Mar;
98(7):3982-7.
PMID: 11274420
Langerhans cells are a subset of dendritic cells (DCs) found in the human epidermis with unique morphological and molecular properties that enable their function as "sentinels" of the immune system....
10.
Row P, Reaves B, Domin J, Luzio J, Davidson H
Biochem J
. 2001 Feb;
353(Pt 3):655-61.
PMID: 11171063
Lipid kinases and their phosphorylated products are important regulators of many cellular processes, including intracellular membrane traffic. The best example of this is provided by the class III phosphoinositide 3-kinase...