J Nicholas ODonnell
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Explore the profile of J Nicholas ODonnell including associated specialties, affiliations and a list of published articles.
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36
Citations
415
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Recent Articles
11.
ODonnell J, Novak G, Bratek B, Singh G, Duru O, Mitchell C, et al.
Int J Antimicrob Agents
. 2021 Feb;
57(4):106311.
PMID: 33621602
Clostridioides difficile infection (CDI) is a significant cause of morbidity and mortality. Oral vancomycin is a cornerstone of CDI treatment, but dosing strategies in clinical practice may differ from guideline...
12.
Avedissian S, Pais G, Liu J, ODonnell J, Lodise T, Neely M, et al.
Antimicrob Agents Chemother
. 2020 Dec;
65(3).
PMID: 33318004
Vancomycin induces exposure-related acute kidney injury. However, the pharmacokinetic-toxicodynamic (PK-TD) relationship remains unclear. Sprague-Dawley rats received intravenous (i.v.) vancomycin doses of 300 mg/kg/day and 400 mg/kg/day, divided into once-, twice-,...
13.
ODonnell J, Bidell M, Lodise T
Pharmacotherapy
. 2020 Jul;
40(9):952-969.
PMID: 32696452
Multidrug resistance(MDR) among Pseudomonas aeruginosa (PSA) isolates presents a significant clinical challenge and can substantially complicate the approach to selection of optimal antibiotic therapy. This review addresses major considerations in...
14.
ODonnell J, Xu A, Lodise T
Clin Ther
. 2020 Jul;
42(8):1580-1586.e2.
PMID: 32684326
Purpose: The objective of this communication was to determine the intravenous compatibility of ceftazidime/avibactam and aztreonam using simulated and actual Y-site administration. Methods: Ceftazidime-avibactam was reconstituted and diluted to concentrations...
15.
ODonnell J, Rhodes N, Biehle L, Esterly J, Patel T, McLaughlin M, et al.
Int J Antimicrob Agents
. 2019 Nov;
55(2):105849.
PMID: 31770628
In 2010, the Clinical and Laboratory Standards Institute (CLSI) lowered carbapenem breakpoints to reduce the proportion of 'susceptible' organisms that produced carbapenemases. Few studies have evaluated the effect of this...
16.
Avedissian S, Pais G, ODonnell J, Lodise T, Liu J, Prozialeck W, et al.
J Antimicrob Chemother
. 2019 May;
74(8):2326-2334.
PMID: 31065686
Objectives: To identify the pharmacokinetic (PK) and toxicodynamic (TD) relationship for vancomycin-induced kidney injury. Methods: Male Sprague-Dawley rats received intravenous (iv) vancomycin. Doses ranging from 150 mg/kg/day to 400 mg/kg/day...
17.
Pais G, Avedissian S, ODonnell J, Rhodes N, Lodise T, Prozialeck W, et al.
Antimicrob Agents Chemother
. 2019 Apr;
63(7).
PMID: 30988153
Urinary biomarkers are superior to serum creatinine for defining onset and extent of kidney injury. This study classifies the temporal predictive ability of biomarkers for vancomycin-induced kidney injury (VIKI) as...
18.
Bidell M, Patel N, ODonnell J
J Antimicrob Chemother
. 2018 Aug;
73(10):2643-2651.
PMID: 30085140
Background: Bacteraemias caused by MSSA are associated with significant morbidity and mortality. Controversy exists over the optimal treatment of severe infections caused by MSSA. This systematic review and meta-analysis aims...
19.
Wang S, Gilchrist A, Loukitcheva A, Plotkin B, Sigar I, Gross A, et al.
Antimicrob Agents Chemother
. 2018 Jun;
62(8).
PMID: 29891607
The efficacy of cefazolin with high-inoculum methicillin-susceptible (MSSA) infections remains in question due to therapeutic failure inferred as being due to an inoculum effect (InE). This study investigated the local...
20.
ODonnell J, Rhodes N, Lopez J, Jett R, Scheetz M
Int J Antimicrob Agents
. 2018 Apr;
52(4):451-458.
PMID: 29665442
Background: Carbapenems have shown efficacy in treating nosocomial pneumonias in clinical trials despite a reported low lung penetration compared with other β-lactams. Preserving the clinical activity of carbapenems through stewardship...