J N Rodriguez-Lopez
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Explore the profile of J N Rodriguez-Lopez including associated specialties, affiliations and a list of published articles.
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61
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747
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Recent Articles
11.
Navarro-Martinez M, Cabezas-Herrera J, Garcia-Canovas F, Rodriguez-Lopez J
J Enzyme Inhib Med Chem
. 2007 Sep;
22(4):377-82.
PMID: 17847703
Although antifolates such as trimethoprim are used in the clinical treatment of Stenotrophomonas maltophilia infection, the dihydrofolate reductase (DHFR) of this microorganism is scarcely known because it has never been...
12.
Munoz J, Garcia-Molina F, Varon R, Rodriguez-Lopez J, Garcia-Ruiz P, Garcia-Canovas F, et al.
J Agric Food Chem
. 2007 Feb;
55(3):920-8.
PMID: 17263494
Chlorogenic acid is the major diphenol of many fruits, where it is oxidized enzymatically by polyphenol oxidase (PPO) or peroxidase (POD) to its o-quinone. In spectrophotometric studies of chlorogenic acid...
13.
Calculating molar absorptivities for quinones: application to the measurement of tyrosinase activity
Munoz J, Garcia-Molina F, Varon R, Rodriguez-Lopez J, Garcia-Canovas F, Tudela J
Anal Biochem
. 2006 Feb;
351(1):128-38.
PMID: 16476401
The molar absorptivities of the quinones produced from different o-diphenols, triphenols, and flavonoids were calculated by generating the respective quinones through oxidation with an excess of periodate. Oxidation of these...
14.
Garcia-Molina F, Penalver M, Rodriguez-Lopez J, Garcia-Canovas F, Tudela J
J Agric Food Chem
. 2005 Aug;
53(16):6183-9.
PMID: 16076091
Thiols, such as cysteine and N-acetylcysteine, are included in many pharmaceutical products for their mucolytic properties. The method described here uses mushroom polyphenol oxidase (PPO) to determine two thiols and...
15.
Fenoll L, Penalver M, Rodriguez-Lopez J, Varon R, Garcia-Canovas F, Tudela J
Int J Biochem Cell Biol
. 2003 Dec;
36(2):235-46.
PMID: 14643889
The kinetic behaviour of tyrosinase is very complex because the enzymatic oxidation of monophenol and o-diphenol to o-quinones occurs simultaneously with the coupled non-enzymatic reactions of the latter. Both reaction...
16.
Fenoll L, Rodriguez-Lopez J, Garcia-Molina F, Garcia-Canovas F, Tudela J
IUBMB Life
. 2002 Dec;
54(3):137-41.
PMID: 12489641
In order to unify and generalize, we define the International Units used to express the monophenolase and diphenolase activity of mushroom tyrosinase acting on different monophenol/diphenol pairs and establish a...
17.
Penalver M, Rodriguez-Lopez J, Garcia-Molina F, Garcia-Canovas F, Tudela J
Anal Biochem
. 2002 Nov;
309(2):180-5.
PMID: 12413449
Metabolic thiols such as cysteine and glutathione are involved in the biosynthetic pathway of phaeomelanins. They attack the o-quinones generated by polyphenol oxidase in its action on mono and o-diphenols...
18.
Rodriguez-Lopez J, Lowe D, Hernandez-Ruiz J, Hiner A, Garcia-Canovas F, Thorneley R
J Am Chem Soc
. 2001 Nov;
123(48):11838-47.
PMID: 11724589
The mechanism of the reaction of horseradish peroxidase isoenzyme C (HRPC) with hydrogen peroxide to form the reactive enzyme intermediate compound I has been studied using electronic absorbance, rapid-scan stopped-flow,...
19.
Rodriguez-Lopez J, Fenoll L, Penalver M, Garcia-Ruiz P, Varon R, Martinez-Ortiz F, et al.
Biochim Biophys Acta
. 2001 Aug;
1548(2):238-56.
PMID: 11513969
Using gas chromatography-mass spectrometry, the direct enzymatic release of o-diphenol (4-tert-butylcatechol) during the action of tyrosinase on a monophenol (4-tert-butylphenol) has been demonstrated for the first time in the literature....
20.
Hiner A, Hernandez-Ruiz J, Rodriguez-Lopez J, Arnao M, Varon R, Garcia-Canovas F, et al.
J Biol Inorg Chem
. 2001 Jul;
6(5-6):504-16.
PMID: 11472014
The inactivation of horseradish peroxidase A2 (HRP-A2) with H2O2 as the sole substrate has been studied. In incubation experiments it was found that the fall in HRP-A2 activity was non-linearly...