J N Octave
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Explore the profile of J N Octave including associated specialties, affiliations and a list of published articles.
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73
Citations
530
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Recent Articles
11.
Kienlen-Campard P, Tasiaux B, Octave J
Exp Gerontol
. 2000 Oct;
35(6-7):843-50.
PMID: 11053675
One of the major neuropathological hallmarks of Alzheimer's disease is the presence of senile plaques in vulnerable regions of CNS. These plaques are formed of aggregated amyloid peptide. Amyloid peptide...
12.
Mbella E, Bertrand S, Huez G, Octave J
Mol Cell Biol
. 2000 Jun;
20(13):4572-9.
PMID: 10848584
The alternative polyadenylation of the mRNA encoding the amyloid precursor protein (APP) involved in Alzheimer's disease generates two molecules, with the first of these containing 258 additional nucleotides in the...
13.
Octave J, Essalmani R, Tasiaux B, Menager J, Czech C, Mercken L
J Biol Chem
. 2000 Jan;
275(3):1525-8.
PMID: 10636839
Presenilin-1 (PS1) is required for the release of the intracellular domain of Notch from the plasma membrane as well as for the cleavage of the amyloid precursor protein (APP) at...
14.
Brion J, Tremp G, Octave J
Am J Pathol
. 1999 Jan;
154(1):255-70.
PMID: 9916940
We have generated transgenic mice expressing the shortest human tau protein, the microtubule-associated protein that composes paired helical filaments in Alzheimer's disease. Transgenic tau transcripts and proteins were strongly expressed...
15.
Octave J, Macq A, Brion J
Rev Neurol (Paris)
. 1998 Dec;
154 Suppl 2:S75-81.
PMID: 9834546
No abstract available.
16.
Macq A, Czech C, Essalmani R, Brion J, Maron A, Mercken L, et al.
J Biol Chem
. 1998 Oct;
273(44):28931-6.
PMID: 9786896
Recombinant adenoviruses were used for the expression of human amyloid precursor protein (APP) of Alzheimer's disease in primary cultures of rat cortical neurons and astrocytes. The catabolic pathways of human...
17.
Czech C, Delaere P, Macq A, Reibaud M, Dreisler S, Touchet N, et al.
Brain Res Mol Brain Res
. 1997 Jul;
47(1-2):108-16.
PMID: 9221907
The evidence that betaA4 is central to the pathology of Alzheimer's disease (AD) came from the identification of several missense mutations in the amyloid precursor protein (APP) gene co-segregating with...
18.
Knoops B, Octave J
Neuroreport
. 1997 Feb;
8(3):795-8.
PMID: 9106769
alpha 1-tubulin is an isotype of alpha-tubulin, and its mRNA is expressed in the rodent nervous system. A high level of alpha 1-tubulin mRNA in neurones is associated with axonal...
19.
Maron A, Havaux N, Le Roux A, Knoops B, Perricaudet M, Octave J
Gene Ther
. 1997 Jan;
4(1):25-31.
PMID: 9068792
The toxicity of the suicide HSVtk gene approach is known to be targeted to DNA synthesis and, consequently, to dividing cells. This system is therefore useful for the treatment of...
20.
Philippe B, Brion J, Coppens E, Octave J
J Neurosci Res
. 1996 Dec;
46(6):709-19.
PMID: 8978505
A fusion protein between beta-galactosidase and the amino-terminal domain of amyloid precursor protein (APP) was used as an immunogen for the production of monoclonal antibodies. One of these antibodies, the...