J N Jansonius
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Explore the profile of J N Jansonius including associated specialties, affiliations and a list of published articles.
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97
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2150
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Recent Articles
1.
Hennig M, Darimont B, Jansonius J, Kirschner K
J Mol Biol
. 2002 Jun;
319(3):757-66.
PMID: 12054868
Indoleglycerol phosphate synthase catalyzes the ring closure of an N-alkylated anthranilate to a 3-alkyl indole derivative, a reaction requiring Lewis acid catalysis in vitro. Here, we investigated the enzymatic reaction...
2.
Burkhard P, Dominici P, Jansonius J, Malashkevich V
Nat Struct Biol
. 2001 Oct;
8(11):963-7.
PMID: 11685243
DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively. DDC has been implicated in a number...
3.
Burkhard P, Tai C, Jansonius J, Cook P
J Mol Biol
. 2000 Oct;
303(2):279-86.
PMID: 11023792
A new crystal structure of O-acetylserine sulfhydrylase (OASS) has been solved with chloride bound at an allosteric site and sulfate bound at the active site. The bound anions result in...
4.
Capitani G, Delval G, Morris M, Jansonius J, Schurmann P
J Mol Biol
. 2000 Aug;
302(1):135-54.
PMID: 10964566
Thioredoxins are small ubiquitous proteins which act as general protein disulfide reductases in living cells. Chloroplasts contain two distinct thioredoxins ( f and m) with different phylogenetic origin. Both act...
5.
Capitani G, Hohenester E, Feng L, Storici P, KIRSCH J, Jansonius J
J Mol Biol
. 1999 Dec;
294(3):745-56.
PMID: 10610793
The 2.4 A crystal structure of the vitamin B6-dependent enzyme 1-aminocyclopropane-1-carboxylate (ACC) synthase is described. This enzyme catalyses the committed step in the biosynthesis of ethylene, a plant hormone that...
6.
Malashkevich V, Strop P, Keller J, Jansonius J, Toney M
J Mol Biol
. 1999 Nov;
294(1):193-200.
PMID: 10556038
The crystal structures of four inhibitor complexes of dialkylglycine decarboxylase are reported. The enzyme does not undergo a domain closure, as does aspartate aminotransferase, upon inhibitor binding. Two active-site conformations...
7.
Graber R, Kasper P, Malashkevich V, Strop P, Gehring H, Jansonius J, et al.
J Biol Chem
. 1999 Oct;
274(44):31203-8.
PMID: 10531314
The conjoint substitution of three active-site residues in aspartate aminotransferase (AspAT) of Escherichia coli (Y225R/R292K/R386A) increases the ratio of L-aspartate beta-decarboxylase activity to transaminase activity >25 million-fold. This result was...
8.
Burkhard P, Tai C, Ristroph C, Cook P, Jansonius J
J Mol Biol
. 1999 Aug;
291(4):941-53.
PMID: 10452898
Covalent binding of L-methionine as an external aldimine to the pyridoxal 5'-phosphate-cofactor in the K41A mutant of O-acetylserine sulfhydrylase from Salmonella typhimurium induces a large conformational change in the protein....
9.
The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications
Knochel T, Ivens A, Hester G, Gonzalez A, Bauerle R, Wilmanns M, et al.
Proc Natl Acad Sci U S A
. 1999 Aug;
96(17):9479-84.
PMID: 10449718
Anthranilate synthase catalyzes the synthesis of anthranilate from chorismate and glutamine and is feedback-inhibited by tryptophan. The enzyme of the hyperthermophile Sulfolobus solfataricus has been crystallized in the absence of...
10.
Storici P, Capitani G, de Biase D, Moser M, John R, Jansonius J, et al.
Biochemistry
. 1999 Jul;
38(27):8628-34.
PMID: 10393538
gamma-Aminobutyrate aminotransferase (GABA-AT), a pyridoxal phosphate-dependent enzyme, is responsible for the degradation of the inhibitory neurotransmitter GABA and is a target for antiepileptic drugs because its selective inhibition raises GABA...